DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_SCF_FBW7_1

Location: 394:401

E3 ligase: FBXW7

DEGRON score: 0.9869

ASA_SCORE: 92.6125

COIL: 0.8894

CONS_SCORE: 0.3316

DSS_SCORE: 0.503

HELIX: 0.0644

FCONS_SCORE: 0.7689

RIG_SCORE: 0.7128

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R397H	TCGA-17-Z045	LUAD	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.8244
p.R397L	TCGA-34-7107	LUSC	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.8428
p.R397L	DO26449	LUSC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.8428
p.P390H	TCGA-AX-A2HC	UCEC	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390H	DO41572	UCEC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390L	TCGA-CV-7568	HNSC	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390L	TCGA-EE-A29D	SKCM	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390L	DO14160	HNSC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390L	DO38123	SKCM	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390S	TCGA-EB-A85J	SKCM	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.P390S	DO50297	SKCM	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.2222
p.E409G	TCGA-HC-A6AO	PRAD	TCGA	IGWTPEKT	DEG_SCF_FBW7_1	0.1111
p.E409G	DO49825	PRAD	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.1111
p.R397C	DO233105	GACA	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.8301
p.M388I	DO229027	LICA	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.1667
p.M408I	DO24547	LUAD	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.1389
p.M408K	DO24547	LUAD	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.1389
p.S391Y	DO31250	OV	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.25
p.V386A	DO42105	UCEC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.1111
p.E402D	DO43907	UCEC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.3056
p.N406D	DO41211	UCEC	ICGC	IGWTPEKT	DEG_SCF_FBW7_1	0.6389
p.E392D	SIDM00614	Hepatocellular Carcinoma	GDSC	IGWTPEKT	DEG_SCF_FBW7_1	0.2778
p.E392D	ACH-000848	Liver Cancer	CCLE	IGWTPEKT	DEG_SCF_FBW7_1	0.2778
p.E392D	JHH-7	liver	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.2778
p.D385G	SIDM00537	Colorectal Carcinoma	GDSC	IGWTPEKT	DEG_SCF_FBW7_1	0.0833
p.D385G	ACH-000982	Colon/Colorectal Cancer	CCLE	IGWTPEKT	DEG_SCF_FBW7_1	0.0833
p.D385G	ACH-001345	Colon/Colorectal Cancer	CCLE	IGWTPEKT	DEG_SCF_FBW7_1	0.0833
p.D385G	GP5d	large_intestine	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.0833
p.L398F	NCI-H1770	lung	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.6981
p.D401Y	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.7325
p.E403K	NCI-H187	lung	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.2778
p.E404Q	HT-1376	urinary_tract	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.25
p.V409A	SNU-1040	large_intestine	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.1111
p.D393A	SISO	cervix	COSMIC	IGWTPEKT	DEG_SCF_FBW7_1	0.75

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IGWTPEKT

Degron related mutations and impact score

Drug responses associated with KIAA0586 mutations

All proteins holding degron of IGWTPEKT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_SCF_FBW7_1	394:401	IGWTPEKT	FBXW7	0.9869	More...