DegronMD

Uniprot ID: Q9BVV6

Source protein: Protein TALPID3

Source gene: KIAA0586

Class: DEG_SCF_FBW7_1

Location: 1060:1067

E3 ligase: FBXW7

DEGRON score: 0.9828

ASA_SCORE: 95.2875

COIL: 0.9699

CONS_SCORE: 0.6034

DSS_SCORE: 0.4102

HELIX: 0.0094

FCONS_SCORE: 1.5974

RIG_SCORE: 0.6715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1077T	TCGA-98-A538	LUSC	TCGA	LVKTPDSS	DEG_SCF_FBW7_1	0.0556
p.A1067T	TCGA-AA-3864	COAD	TCGA	LVKTPDSS	DEG_SCF_FBW7_1	0.7139
p.P1052S	TCGA-EE-A29L	SKCM	TCGA	LVKTPDSS	DEG_SCF_FBW7_1	0.1111
p.K1059N	SIDM00602	Gastric Carcinoma	GDSC	LVKTPDSS	DEG_SCF_FBW7_1	0.3056
p.K1059N	ACH-000919	Gastric Cancer	CCLE	LVKTPDSS	DEG_SCF_FBW7_1	0.3056
p.K1059N	IM-95	stomach	COSMIC	LVKTPDSS	DEG_SCF_FBW7_1	0.3056
p.N1054K	SIDM00674	Non-Cancerous	GDSC	LVKTPDSS	DEG_SCF_FBW7_1	0.1667
p.N1054K	SIDM00675	Breast Carcinoma	GDSC	LVKTPDSS	DEG_SCF_FBW7_1	0.1667
p.N1054K	SIDM01009	Neuroblastoma	GDSC	LVKTPDSS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVV6	Protein TALPID3	DEG_SCF_FBW7_1	1060:1067	LVKTPDSS	FBXW7	0.9828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons