DegronMD

Uniprot ID: Q7Z589

Source protein: BRCA2-interacting transcriptional repressor EMSY

Source gene: EMSY

Class: DEG_COP1_1

Location: 609:619

E3 ligase: COP1

DEGRON score: 0.9094

ASA_SCORE: 95.3727

COIL: 0.8461

CONS_SCORE: 0.4358

DSS_SCORE: 0.4049

HELIX: 0.0175

FCONS_SCORE: 0.9887

RIG_SCORE: 0.7879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T600I	SIDM00373	Endometrial Carcinoma	GDSC	EKTIQTVPTGA	DEG_COP1_1	0.0833
p.T600I	SNG-M	endometrium	COSMIC	EKTIQTVPTGA	DEG_COP1_1	0.0833
p.T599I	SNG-M	endometrium	COSMIC	EKTIQTVPTGA	DEG_COP1_1	0.0556
p.S620L	OCI-M1	haematopoietic_and_lymphoid_tissue	COSMIC	EKTIQTVPTGA	DEG_COP1_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z589	BRCA2-interacting transcriptional repressor EMSY	DEG_COP1_1	609:619	EKTIQTVPTGA	COP1	0.9094	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons