DegronMD - Q7Z589(EMSY)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q879R	SIDM00789	Colorectal Carcinoma	GDSC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.1944
p.Q879R	HCT-15	large intestine	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.1944
p.P145S	SIDM00190	Melanoma	GDSC	PTSTPVPS	DEG_SCF_FBW7_1	153:160	Mutation rewiring degron network	0.1111
p.P145S	CP66-MEL	skin	COSMIC	PTSTPVPS	DEG_SCF_FBW7_1	153:160	Mutation rewiring degron network	0.1111
p.I509V	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.25
p.I509V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.25
p.T600I	SIDM00373	Endometrial Carcinoma	GDSC	EKTIQTVPTGA	DEG_COP1_1	609:619	Mutation rewiring degron network	0.0833
p.T600I	SNG-M	endometrium	COSMIC	EKTIQTVPTGA	DEG_COP1_1	609:619	Mutation rewiring degron network	0.0833
p.L863R	TE-11	oesophagus	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.25
p.L863R	HuP-T4	pancreas	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.25
p.L863R	OVKATE	ovary	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.25
p.L863R	no-11	central nervous system	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.25
p.T599I	SNG-M	endometrium	COSMIC	EKTIQTVPTGA	DEG_COP1_1	609:619	Mutation rewiring degron network	0.0556
p.I494V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.Q864R	HCT-15	large intestine	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.2778
p.V494M	SC-1	haematopoietic and lymphoid tissue	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.V494M	KMRC-20	kidney	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.1944
p.L856R	OVKATE	ovary	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.0556
p.L856R	HuP-T4	pancreas	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.0556
p.L856R	TE-11	oesophagus	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.0556
p.L856R	no-11	central nervous system	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.0556
p.Q875H	NCI-H727	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.3056
p.I508V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2778
p.Q865R	HCT-15	large intestine	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.3056
p.Q865R	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.3056
p.S620L	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	EKTIQTVPTGA	DEG_COP1_1	609:619	Mutation blocking ubiquitination signal	0.75
p.P860L	HCC-15	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.1667
p.T501I	SNG-M	endometrium	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation altering degron motif	0.5966
p.P867L	HCC-15	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation altering degron motif	0.7582
p.Q882H	NCI-H727	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation rewiring degron network	0.1111
p.I495V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	499:506	Mutation rewiring degron network	0.2222
p.Q872R	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	866:874	Mutation altering degron motif	0.7329

Kaplan plot for EMSY in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EMSY

UniProt ID: Q7Z589

Entrez ID: 56946

Protein name: BRCA2-interacting transcriptional repressor EMSY

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EMSY in