DegronMD

Uniprot ID: Q7Z589

Source protein: BRCA2-interacting transcriptional repressor EMSY

Source gene: EMSY

Class: DEG_SCF_FBW7_1

Location: 499:506

E3 ligase: FBXW7

DEGRON score: 0.9942

ASA_SCORE: 86.05

COIL: 0.8303

CONS_SCORE: 0.4634

DSS_SCORE: 0.4567

HELIX: 0.0142

FCONS_SCORE: 0.9843

RIG_SCORE: 0.769

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I509V	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	LVTTPTGT	DEG_SCF_FBW7_1	0.25
p.I509V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.25
p.I494V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.1944
p.V494M	SC-1	haematopoietic_and_lymphoid_tissue	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.1944
p.V494M	KMRC-20	kidney	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.1944
p.I508V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.2778
p.T501I	SNG-M	endometrium	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.5966
p.I495V	NCI-H596	lung	COSMIC	LVTTPTGT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z589	BRCA2-interacting transcriptional repressor EMSY	DEG_SCF_FBW7_1	499:506	LVTTPTGT	FBXW7	0.9942	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons