DegronMD

Uniprot ID: Q7Z589

Source protein: BRCA2-interacting transcriptional repressor EMSY

Source gene: EMSY

Class: DEG_APCC_DBOX_1

Location: 866:874

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9368

ASA_SCORE: 108.5222

COIL: 0.75

CONS_SCORE: 0.3585

DSS_SCORE: 0.6226

HELIX: 0.1164

FCONS_SCORE: 0.967

RIG_SCORE: 0.7345

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q879R	SIDM00789	Colorectal Carcinoma	GDSC	QRTLLQHVA	DEG_APCC_DBOX_1	0.1944
p.Q879R	HCT-15	large_intestine	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.1944
p.L863R	TE-11	oesophagus	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.25
p.L863R	HuP-T4	pancreas	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.25
p.L863R	OVKATE	ovary	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.25
p.L863R	no-11	central_nervous_system	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.25
p.Q864R	HCT-15	large_intestine	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.2778
p.L856R	OVKATE	ovary	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.0556
p.L856R	HuP-T4	pancreas	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.0556
p.L856R	TE-11	oesophagus	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.0556
p.L856R	no-11	central_nervous_system	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.0556
p.Q875H	NCI-H727	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.3056
p.Q865R	HCT-15	large_intestine	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.3056
p.Q865R	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.3056
p.P860L	HCC-15	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.1667
p.P867L	HCC-15	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.7582
p.Q882H	NCI-H727	lung	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.1111
p.Q872R	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	QRTLLQHVA	DEG_APCC_DBOX_1	0.7329

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7Z589	BRCA2-interacting transcriptional repressor EMSY	DEG_APCC_DBOX_1	866:874	QRTLLQHVA	APC,CDC20,FZR1	0.9368	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons