DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PTSTPVPS
Uniprot ID:
Q7Z589
Source protein:
BRCA2-interacting transcriptional repressor EMSY
Source gene:
EMSY
Class:
DEG_SCF_FBW7_1
Location:
153:160
E3 ligase:
FBXW7
DEGRON score:
0.9501
ASA_SCORE:
92.325
COIL:
0.9671
CONS_SCORE:
0.3966
DSS_SCORE:
0.4846
HELIX:
0.0113
FCONS_SCORE:
1.0167
RIG_SCORE:
0.6574
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P145S
SIDM00190
Melanoma
GDSC
PTSTPVPS
DEG_SCF_FBW7_1
0.1111
p.P145S
CP66-MEL
skin
COSMIC
PTSTPVPS
DEG_SCF_FBW7_1
0.1111
Drug responses associated with EMSY mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PTSTPVPS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q7Z589
BRCA2-interacting transcriptional repressor EMSY
DEG_SCF_FBW7_1
153:160
PTSTPVPS
FBXW7
0.9501
More...