DegronMD

Uniprot ID: Q6UVK1

Source protein: Chondroitin sulfate proteoglycan 4

Source gene: CSPG4

Class: DEG_COP1_1

Location: 410:419

E3 ligase: COP1

DEGRON score: 0.9852

ASA_SCORE: 68.01

COIL: 0.7728

CONS_SCORE: 0.3159

DSS_SCORE: 0.3777

HELIX: 0.0433

FCONS_SCORE: 1.1309

RIG_SCORE: 0.7437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P422S	TCGA-AA-A010	COAD	TCGA	ELPEPCVPEP	DEG_COP1_1	0.25
p.P407S	TCGA-AP-A059	UCEC	TCGA	ELPEPCVPEP	DEG_COP1_1	0.25
p.P407S	DO41361	UCEC	ICGC	ELPEPCVPEP	DEG_COP1_1	0.25
p.P423H	TCGA-D3-A3CE	SKCM	TCGA	ELPEPCVPEP	DEG_COP1_1	0.2222
p.P423H	DO37405	SKCM	ICGC	ELPEPCVPEP	DEG_COP1_1	0.2222
p.P412S	TCGA-VQ-A924	STAD	TCGA	ELPEPCVPEP	DEG_COP1_1	0.5641
p.P412S	DO51795	STAD	ICGC	ELPEPCVPEP	DEG_COP1_1	0.5641
p.P412S	SIDM01293	Colorectal Carcinoma	GDSC	ELPEPCVPEP	DEG_COP1_1	0.5641
p.G420W	DO224768	BRCA	ICGC	ELPEPCVPEP	DEG_COP1_1	0.3056
p.P407L	DO50966	LICA	ICGC	ELPEPCVPEP	DEG_COP1_1	0.25
p.C415F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ELPEPCVPEP	DEG_COP1_1	0.5996
p.C415F	ACH-002256	Leukemia	CCLE	ELPEPCVPEP	DEG_COP1_1	0.5996
p.C415F	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	ELPEPCVPEP	DEG_COP1_1	0.5996
p.T400P	639-V	urinary_tract	COSMIC	ELPEPCVPEP	DEG_COP1_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UVK1	Chondroitin sulfate proteoglycan 4	DEG_COP1_1	410:419	ELPEPCVPEP	COP1	0.9852	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons