DegronMD - Q6UVK1(CSPG4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G325R	TCGA-06-0171	GBM	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1111
p.G325R	TCGA-VS-A8Q8	CESC	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1111
p.G325R	DO51625	CESC	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1111
p.G325R	DO222285	GACA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1111
p.G325R	DO11382	GBM	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1111
p.A349V	TCGA-77-6845	LUSC	TCGA	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.2778
p.A349V	DO26635	LUSC	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.2778
p.A349V	SIDM01076	B-Lymphoblastic Leukemia	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.2778
p.A349V	697	haematopoietic and lymphoid tissue	COSMIC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.2778
p.S308L	TCGA-AA-3984	COAD	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.S308L	TCGA-CA-6717	COAD	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.S308L	TCGA-EE-A3AC	SKCM	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.S308L	DO9002	COAD	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.S308L	DO8264	COAD	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.S308L	DO37631	SKCM	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.P422S	TCGA-AA-A010	COAD	TCGA	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.25
p.P407S	TCGA-AP-A059	UCEC	TCGA	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.25
p.P407S	DO41361	UCEC	ICGC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.25
p.R333H	TCGA-AX-A2HD	UCEC	TCGA	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R333H	DO229056	LICA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R333H	DO229229	THCA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R333H	DO42608	UCEC	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R319W	TCGA-CV-6948	HNSC	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2778
p.R319W	DO14188	HNSC	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2778
p.P423H	TCGA-D3-A3CE	SKCM	TCGA	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.2222
p.P423H	DO37405	SKCM	ICGC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.2222
p.H338Q	TCGA-EO-A22U	UCEC	TCGA	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.2778
p.H338Q	DO43755	UCEC	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.2778
p.L316M	TCGA-VQ-A8P2	STAD	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5999
p.L316M	DO51761	STAD	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation altering degron motif	0.5999
p.P412S	TCGA-VQ-A924	STAD	TCGA	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation altering degron motif	0.5641
p.P412S	DO51795	STAD	ICGC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation altering degron motif	0.5641
p.P412S	SIDM01293	Colorectal Carcinoma	GDSC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation altering degron motif	0.5641
p.G420W	DO224768	BRCA	ICGC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.3056
p.R339C	DO228404	BRCA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.R339C	SIDM01156	Small Cell Lung Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.R339C	SIDM00646	Small Cell Lung Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.R339C	SIDM01076	B-Lymphoblastic Leukemia	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.R339C	SIDM01146	Gastric Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.C354R	DO234222	ESAD	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.T305K	DO229026	LICA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.G341D	DO50788	LICA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.6087
p.P407L	DO50966	LICA	ICGC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.25
p.G341S	DO52688	MALY	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.5882
p.A331V	DO220886	MELA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0833
p.A331T	DO222363	MELA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.0833
p.G325K	DO222837	MELA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.1111
p.E345G	DO51511	PACA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.6087
p.T343I	DO51511	PACA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation altering degron motif	0.7078
p.T305M	DO229485	SKCA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.2222
p.C415F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation altering degron motif	0.5996
p.C415F	ACH-002256	Leukemia	CCLE	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation altering degron motif	0.5996
p.C415F	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation altering degron motif	0.5996
p.R333P	SIDM01005	Acute Myeloid Leukemia	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R333P	SIDM01659	Kidney Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R333P	ACH-000263	Leukemia	CCLE	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.R333P	ACH-000313	Kidney Cancer	CCLE	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.1389
p.P318A	SIDM00685	Glioblastoma	GDSC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.P318A	ACH-000819	Brain Cancer	CCLE	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.P318A	LN-18	central nervous system	COSMIC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.3056
p.N348S	SIDM00068	Colorectal Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.N348S	ACH-002394	Colon/Colorectal Cancer	CCLE	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.N348S	GEO	large intestine	COSMIC	LGLTPEAT	DEG_SCF_FBW7_1	340:347	Mutation rewiring degron network	0.3056
p.S299F	SIDM00217	Colorectal Carcinoma	GDSC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.S299F	ACH-000999	Colon/Colorectal Cancer	CCLE	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.S299F	SNU-1040	large intestine	COSMIC	NRGVLSYLE	DEG_APCC_DBOX_1	309:317	Mutation rewiring degron network	0.0556
p.T400P	639-V	urinary tract	COSMIC	ELPEPCVPEP	DEG_COP1_1	410:419	Mutation rewiring degron network	0.0556

Kaplan plot for CSPG4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CSPG4

UniProt ID: Q6UVK1

Entrez ID: 1464

Protein name: Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CSPG4 in