DegronMD

Uniprot ID: Q6UVK1

Source protein: Chondroitin sulfate proteoglycan 4

Source gene: CSPG4

Class: DEG_SCF_FBW7_1

Location: 340:347

E3 ligase: FBXW7

DEGRON score: 0.9331

ASA_SCORE: 55.5

COIL: 0.793

CONS_SCORE: 0.3169

DSS_SCORE: 0.395

HELIX: 0.1573

FCONS_SCORE: 0.7799

RIG_SCORE: 0.7135

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A349V	TCGA-77-6845	LUSC	TCGA	LGLTPEAT	DEG_SCF_FBW7_1	0.2778
p.A349V	DO26635	LUSC	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.2778
p.A349V	SIDM01076	B-Lymphoblastic Leukemia	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.2778
p.A349V	697	haematopoietic_and_lymphoid_tissue	COSMIC	LGLTPEAT	DEG_SCF_FBW7_1	0.2778
p.R333H	TCGA-AX-A2HD	UCEC	TCGA	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.R333H	DO229056	LICA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.R333H	DO229229	THCA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.R333H	DO42608	UCEC	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.H338Q	TCGA-EO-A22U	UCEC	TCGA	LGLTPEAT	DEG_SCF_FBW7_1	0.2778
p.H338Q	DO43755	UCEC	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.2778
p.R339C	DO228404	BRCA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.R339C	SIDM01156	Small Cell Lung Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.R339C	SIDM00646	Small Cell Lung Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.R339C	SIDM01076	B-Lymphoblastic Leukemia	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.R339C	SIDM01146	Gastric Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.C354R	DO234222	ESAD	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.G341D	DO50788	LICA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.6087
p.G341S	DO52688	MALY	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.5882
p.A331V	DO220886	MELA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.0833
p.A331T	DO222363	MELA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.0833
p.E345G	DO51511	PACA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.6087
p.T343I	DO51511	PACA	ICGC	LGLTPEAT	DEG_SCF_FBW7_1	0.7078
p.R333P	SIDM01005	Acute Myeloid Leukemia	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.R333P	SIDM01659	Kidney Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.R333P	ACH-000263	Leukemia	CCLE	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.R333P	ACH-000313	Kidney Cancer	CCLE	LGLTPEAT	DEG_SCF_FBW7_1	0.1389
p.N348S	SIDM00068	Colorectal Carcinoma	GDSC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.N348S	ACH-002394	Colon/Colorectal Cancer	CCLE	LGLTPEAT	DEG_SCF_FBW7_1	0.3056
p.N348S	GEO	large_intestine	COSMIC	LGLTPEAT	DEG_SCF_FBW7_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGLTPEAT

Degron related mutations and impact score

Drug responses associated with CSPG4 mutations

All proteins holding degron of LGLTPEAT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UVK1	Chondroitin sulfate proteoglycan 4	DEG_SCF_FBW7_1	340:347	LGLTPEAT	FBXW7	0.9331	More...