DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
NRGVLSYLE
Uniprot ID:
Q6UVK1
Source protein:
Chondroitin sulfate proteoglycan 4
Source gene:
CSPG4
Class:
DEG_APCC_DBOX_1
Location:
309:317
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7103
ASA_SCORE:
67.3667
COIL:
0.3859
CONS_SCORE:
0.2672
DSS_SCORE:
0.3819
HELIX:
0.016
FCONS_SCORE:
0.623
RIG_SCORE:
0.7615
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G325R
TCGA-06-0171
GBM
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.1111
p.G325R
TCGA-VS-A8Q8
CESC
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.1111
p.G325R
DO51625
CESC
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.1111
p.G325R
DO222285
GACA
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.1111
p.G325R
DO11382
GBM
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.1111
p.S308L
TCGA-AA-3984
COAD
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.S308L
TCGA-CA-6717
COAD
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.S308L
TCGA-EE-A3AC
SKCM
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.S308L
DO9002
COAD
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.S308L
DO8264
COAD
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.S308L
DO37631
SKCM
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.R319W
TCGA-CV-6948
HNSC
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.2778
p.R319W
DO14188
HNSC
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.2778
p.L316M
TCGA-VQ-A8P2
STAD
TCGA
NRGVLSYLE
DEG_APCC_DBOX_1
0.5999
p.L316M
DO51761
STAD
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.5999
p.T305K
DO229026
LICA
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.2222
p.G325K
DO222837
MELA
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.1111
p.T305M
DO229485
SKCA
ICGC
NRGVLSYLE
DEG_APCC_DBOX_1
0.2222
p.P318A
SIDM00685
Glioblastoma
GDSC
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.P318A
ACH-000819
Brain Cancer
CCLE
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.P318A
LN-18
central_nervous_system
COSMIC
NRGVLSYLE
DEG_APCC_DBOX_1
0.3056
p.S299F
SIDM00217
Colorectal Carcinoma
GDSC
NRGVLSYLE
DEG_APCC_DBOX_1
0.0556
p.S299F
ACH-000999
Colon/Colorectal Cancer
CCLE
NRGVLSYLE
DEG_APCC_DBOX_1
0.0556
p.S299F
SNU-1040
large_intestine
COSMIC
NRGVLSYLE
DEG_APCC_DBOX_1
0.0556
Drug responses associated with CSPG4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NRGVLSYLE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6UVK1
Chondroitin sulfate proteoglycan 4
DEG_APCC_DBOX_1
309:317
NRGVLSYLE
APC,CDC20,FZR1
0.7103
More...