DegronMD

Uniprot ID: Q6UVK1

Source protein: Chondroitin sulfate proteoglycan 4

Source gene: CSPG4

Class: DEG_APCC_DBOX_1

Location: 309:317

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7103

ASA_SCORE: 67.3667

COIL: 0.3859

CONS_SCORE: 0.2672

DSS_SCORE: 0.3819

HELIX: 0.016

FCONS_SCORE: 0.623

RIG_SCORE: 0.7615

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L316M	TCGA-VQ-A8P2	STAD	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.5999
p.L316M	DO51761	STAD	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.5999
p.S308L	TCGA-AA-3984	COAD	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.S308L	TCGA-CA-6717	COAD	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.S308L	TCGA-EE-A3AC	SKCM	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.S308L	DO9002	COAD	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.S308L	DO8264	COAD	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.S308L	DO37631	SKCM	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.P318A	SIDM00685	Glioblastoma	GDSC	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.P318A	ACH-000819	Brain Cancer	CCLE	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.P318A	LN-18	central_nervous_system	COSMIC	NRGVLSYLE	DEG_APCC_DBOX_1	0.3056
p.R319W	TCGA-CV-6948	HNSC	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.2778
p.R319W	DO14188	HNSC	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.2778
p.T305K	DO229026	LICA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.2222
p.T305M	DO229485	SKCA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.2222
p.G325R	TCGA-06-0171	GBM	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.1111
p.G325R	TCGA-VS-A8Q8	CESC	TCGA	NRGVLSYLE	DEG_APCC_DBOX_1	0.1111
p.G325R	DO51625	CESC	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.1111
p.G325R	DO222285	GACA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.1111
p.G325R	DO11382	GBM	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.1111
p.G325K	DO222837	MELA	ICGC	NRGVLSYLE	DEG_APCC_DBOX_1	0.1111
p.S299F	SIDM00217	Colorectal Carcinoma	GDSC	NRGVLSYLE	DEG_APCC_DBOX_1	0.0556
p.S299F	ACH-000999	Colon/Colorectal Cancer	CCLE	NRGVLSYLE	DEG_APCC_DBOX_1	0.0556
p.S299F	SNU-1040	large_intestine	COSMIC	NRGVLSYLE	DEG_APCC_DBOX_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UVK1	Chondroitin sulfate proteoglycan 4	DEG_APCC_DBOX_1	309:317	NRGVLSYLE	APC,CDC20,FZR1	0.7103	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons