DegronMD

Uniprot ID: O94842

Source protein: TOX high mobility group box family member 4

Source gene: TOX4

Class: DEG_COP1_1

Location: 539:548

E3 ligase: COP1

DEGRON score: 0.8801

ASA_SCORE: 87.14

COIL: 0.6712

CONS_SCORE: 0.5147

DSS_SCORE: 0.5727

HELIX: 0.209

FCONS_SCORE: 0.9847

RIG_SCORE: 0.7976

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V548I	TCGA-13-0920	OV	TCGA	EMITDVVPEV	DEG_COP1_1	0.5965
p.L558V	TCGA-AA-A010	COAD	TCGA	EMITDVVPEV	DEG_COP1_1	0.0556
p.S550C	TCGA-BA-4077	HNSC	TCGA	EMITDVVPEV	DEG_COP1_1	0.7222
p.E547K	TCGA-EK-A2RC	CESC	TCGA	EMITDVVPEV	DEG_COP1_1	0.7022
p.D543H	TCGA-IR-A3LK	CESC	TCGA	EMITDVVPEV	DEG_COP1_1	0.6577
p.G553D	DO219108	GBM	ICGC	EMITDVVPEV	DEG_COP1_1	0.1944
p.G538W	DO229019	LICA	ICGC	EMITDVVPEV	DEG_COP1_1	0.3056
p.C549F	DO229029	LICA	ICGC	EMITDVVPEV	DEG_COP1_1	0.3056
p.V550L	DO229009	LICA	ICGC	EMITDVVPEV	DEG_COP1_1	0.7222
p.S552F	SIDM01261	Breast Carcinoma	GDSC	EMITDVVPEV	DEG_COP1_1	0.6667
p.S552F	SIDM00314	Breast Carcinoma	GDSC	EMITDVVPEV	DEG_COP1_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94842	TOX high mobility group box family member 4	DEG_COP1_1	539:548	EMITDVVPEV	COP1	0.8801	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons