DegronMD - O94842(TOX4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V548I	TCGA-13-0920	OV	TCGA	EMITDVVPEV	DEG_COP1_1	539:548	Mutation altering degron motif	0.5965
p.L558V	TCGA-AA-A010	COAD	TCGA	EMITDVVPEV	DEG_COP1_1	539:548	Mutation rewiring degron network	0.0556
p.M319V	TCGA-AG-3894	READ	TCGA	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.6097
p.R172C	TCGA-AP-A051	UCEC	TCGA	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.3056
p.S550C	TCGA-BA-4077	HNSC	TCGA	EMITDVVPEV	DEG_COP1_1	539:548	Mutation blocking phosphorylation signal	0.7222
p.P334S	TCGA-BR-8487	STAD	TCGA	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.0833
p.Q167K	TCGA-EE-A181	SKCM	TCGA	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1667
p.E547K	TCGA-EK-A2RC	CESC	TCGA	EMITDVVPEV	DEG_COP1_1	539:548	Mutation altering degron motif	0.7022
p.D543H	TCGA-IR-A3LK	CESC	TCGA	EMITDVVPEV	DEG_COP1_1	539:548	Mutation altering degron motif	0.6577
p.S181I	TCGA-ZF-AA5H	BLCA	TCGA	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation blocking phosphorylation signal	0.75
p.V320A	DO8018	COAD	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.6936
p.A329T	DO9002	COAD	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.2222
p.P316L	DO8264	COAD	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.3056
p.S317C	DO234333	ESAD	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.7541
p.A329V	DO233259	GACA	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.2222
p.G553D	DO219108	GBM	ICGC	EMITDVVPEV	DEG_COP1_1	539:548	Mutation rewiring degron network	0.1944
p.G538W	DO229019	LICA	ICGC	EMITDVVPEV	DEG_COP1_1	539:548	Mutation rewiring degron network	0.3056
p.C549F	DO229029	LICA	ICGC	EMITDVVPEV	DEG_COP1_1	539:548	Mutation rewiring degron network	0.3056
p.V550L	DO229009	LICA	ICGC	EMITDVVPEV	DEG_COP1_1	539:548	Mutation blocking phosphorylation signal	0.7222
p.V179M	DO49421	PACA	ICGC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.7208
p.P311S	DO47867	STAD	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.1667
p.S325L	DO47989	STAD	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.7667
p.N330K	DO229227	THCA	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.1944
p.P312L	DO229245	THCA	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.1944
p.L314P	DO48172	UCEC	ICGC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation rewiring degron network	0.25
p.K184N	DO41758	UCEC	ICGC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.2222
p.K187N	DO42608	UCEC	ICGC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1389
p.E185K	SIDM00973	Melanoma	GDSC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1944
p.E185K	ACH-000827	Skin Cancer	CCLE	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1944
p.E185K	WM793B	skin	COSMIC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.1944
p.S552F	SIDM01261	Breast Carcinoma	GDSC	EMITDVVPEV	DEG_COP1_1	539:548	Mutation blocking phosphorylation signal	0.6667
p.S552F	SIDM00314	Breast Carcinoma	GDSC	EMITDVVPEV	DEG_COP1_1	539:548	Mutation blocking phosphorylation signal	0.6667
p.D323N	SIDM00465	Ovarian Carcinoma	GDSC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.5821
p.D323N	ACH-002183	Ovarian Cancer	CCLE	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.5821
p.D323N	OVMIU	ovary	COSMIC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.5821
p.P179H	SIDM00901	Endometrial Carcinoma	GDSC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6583
p.P179H	AN3-CA	endometrium	COSMIC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation altering degron motif	0.6583
p.L163M	SIDM01617	Endometrial Carcinoma	GDSC	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.0556
p.L163M	ACH-000994	Endometrial/Uterine Cancer	CCLE	LSTTPSPT	DEG_SCF_FBW7_1	173:180	Mutation rewiring degron network	0.0556
p.M319T	SIDM00161	Biliary Tract Carcinoma	GDSC	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.6312
p.M319T	ACH-000141	Gallbladder Cancer	CCLE	PPMATVDPA	DEG_SIAH_1	317:325	Mutation altering degron motif	0.6312

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TOX4

UniProt ID: O94842

Entrez ID: 9878

Protein name: TOX high mobility group box family member 4 (Epidermal Langerhans cell protein LCP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TOX4 in