DegronMD

Uniprot ID: O94842

Source protein: TOX high mobility group box family member 4

Source gene: TOX4

Class: DEG_SCF_FBW7_1

Location: 173:180

E3 ligase: FBXW7

DEGRON score: 0.9878

ASA_SCORE: 92.4625

COIL: 0.9271

CONS_SCORE: 0.5632

DSS_SCORE: 0.7966

HELIX: 0.0504

FCONS_SCORE: 1.1305

RIG_SCORE: 0.5759

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R172C	TCGA-AP-A051	UCEC	TCGA	LSTTPSPT	DEG_SCF_FBW7_1	0.3056
p.Q167K	TCGA-EE-A181	SKCM	TCGA	LSTTPSPT	DEG_SCF_FBW7_1	0.1667
p.S181I	TCGA-ZF-AA5H	BLCA	TCGA	LSTTPSPT	DEG_SCF_FBW7_1	0.75
p.V179M	DO49421	PACA	ICGC	LSTTPSPT	DEG_SCF_FBW7_1	0.7208
p.K184N	DO41758	UCEC	ICGC	LSTTPSPT	DEG_SCF_FBW7_1	0.2222
p.K187N	DO42608	UCEC	ICGC	LSTTPSPT	DEG_SCF_FBW7_1	0.1389
p.E185K	SIDM00973	Melanoma	GDSC	LSTTPSPT	DEG_SCF_FBW7_1	0.1944
p.E185K	ACH-000827	Skin Cancer	CCLE	LSTTPSPT	DEG_SCF_FBW7_1	0.1944
p.E185K	WM793B	skin	COSMIC	LSTTPSPT	DEG_SCF_FBW7_1	0.1944
p.P179H	SIDM00901	Endometrial Carcinoma	GDSC	LSTTPSPT	DEG_SCF_FBW7_1	0.6583
p.P179H	AN3-CA	endometrium	COSMIC	LSTTPSPT	DEG_SCF_FBW7_1	0.6583
p.L163M	SIDM01617	Endometrial Carcinoma	GDSC	LSTTPSPT	DEG_SCF_FBW7_1	0.0556
p.L163M	ACH-000994	Endometrial/Uterine Cancer	CCLE	LSTTPSPT	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94842	TOX high mobility group box family member 4	DEG_SCF_FBW7_1	173:180	LSTTPSPT	FBXW7	0.9878	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons