DegronMD

Uniprot ID: O94842

Source protein: TOX high mobility group box family member 4

Source gene: TOX4

Class: DEG_SIAH_1

Location: 317:325

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9579

ASA_SCORE: 93.6556

COIL: 0.9451

CONS_SCORE: 0.5117

DSS_SCORE: 0.7136

HELIX: 0.0208

FCONS_SCORE: 0.9865

RIG_SCORE: 0.5959

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M319V	TCGA-AG-3894	READ	TCGA	PPMATVDPA	DEG_SIAH_1	0.6097
p.P334S	TCGA-BR-8487	STAD	TCGA	PPMATVDPA	DEG_SIAH_1	0.0833
p.V320A	DO8018	COAD	ICGC	PPMATVDPA	DEG_SIAH_1	0.6936
p.A329T	DO9002	COAD	ICGC	PPMATVDPA	DEG_SIAH_1	0.2222
p.P316L	DO8264	COAD	ICGC	PPMATVDPA	DEG_SIAH_1	0.3056
p.S317C	DO234333	ESAD	ICGC	PPMATVDPA	DEG_SIAH_1	0.7541
p.A329V	DO233259	GACA	ICGC	PPMATVDPA	DEG_SIAH_1	0.2222
p.P311S	DO47867	STAD	ICGC	PPMATVDPA	DEG_SIAH_1	0.1667
p.S325L	DO47989	STAD	ICGC	PPMATVDPA	DEG_SIAH_1	0.7667
p.N330K	DO229227	THCA	ICGC	PPMATVDPA	DEG_SIAH_1	0.1944
p.P312L	DO229245	THCA	ICGC	PPMATVDPA	DEG_SIAH_1	0.1944
p.L314P	DO48172	UCEC	ICGC	PPMATVDPA	DEG_SIAH_1	0.25
p.D323N	SIDM00465	Ovarian Carcinoma	GDSC	PPMATVDPA	DEG_SIAH_1	0.5821
p.D323N	ACH-002183	Ovarian Cancer	CCLE	PPMATVDPA	DEG_SIAH_1	0.5821
p.D323N	OVMIU	ovary	COSMIC	PPMATVDPA	DEG_SIAH_1	0.5821
p.M319T	SIDM00161	Biliary Tract Carcinoma	GDSC	PPMATVDPA	DEG_SIAH_1	0.6312
p.M319T	ACH-000141	Gallbladder Cancer	CCLE	PPMATVDPA	DEG_SIAH_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94842	TOX high mobility group box family member 4	DEG_SIAH_1	317:325	PPMATVDPA	SIAH1,SIAH2,SIAH3	0.9579	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons