DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
EPASAPVPSP
Uniprot ID:
Q9Y543
Source protein:
Transcription factor HES-2
Source gene:
HES2
Class:
DEG_COP1_1
Location:
151:160
E3 ligase:
COP1
DEGRON score:
0.9848
ASA_SCORE:
99.08
COIL:
0.9698
CONS_SCORE:
0.4488
DSS_SCORE:
0.6374
HELIX:
0.0092
FCONS_SCORE:
1.0487
RIG_SCORE:
0.5123
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G166D
DO229208
THCA
ICGC
EPASAPVPSP
DEG_COP1_1
0.1667
p.A149S
ACH-000665
Lung Cancer
CCLE
EPASAPVPSP
DEG_COP1_1
0.2778
Drug responses associated with HES2 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of EPASAPVPSP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y543
Transcription factor HES-2
DEG_COP1_1
151:160
EPASAPVPSP
COP1
0.9848
More...