DegronMD - Q9Y543(HES2)

HES2

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G8E	TCGA-D3-A2JN	SKCM	TCGA	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.G8E	DO47590	SKCM	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.A11E	DO230326	COCA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.2778
p.R26C	DO233207	GACA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1944
p.R24H	DO233913	GACA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.25
p.G166D	DO229208	THCA	ICGC	EPASAPVPSP	DEG_COP1_1	151:160	Mutation rewiring degron network	0.1667
p.L17M	DO229213	THCA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation altering degron motif	0.711
p.R5H	DO229213	THCA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	13:21	Mutation rewiring degron network	0.1111
p.A149S	ACH-000665	Lung Cancer	CCLE	EPASAPVPSP	DEG_COP1_1	151:160	Mutation rewiring degron network	0.2778

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*NOTE: the Kaplan plots were collected from OncoLnc