DegronMD

Uniprot ID: Q9Y543

Source protein: Transcription factor HES-2

Source gene: HES2

Class: DEG_APCC_DBOX_1

Location: 13:21

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.727

ASA_SCORE: 102.3667

COIL: 0.3887

CONS_SCORE: 0.7069

DSS_SCORE: 0.4123

HELIX: 0.6032

FCONS_SCORE: 1.1544

RIG_SCORE: 0.7712

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G8E	TCGA-D3-A2JN	SKCM	TCGA	LRKSLKPLL	DEG_APCC_DBOX_1	0.1944
p.G8E	DO47590	SKCM	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	0.1944
p.A11E	DO230326	COCA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	0.2778
p.R26C	DO233207	GACA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	0.1944
p.R24H	DO233913	GACA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	0.25
p.L17M	DO229213	THCA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	0.711
p.R5H	DO229213	THCA	ICGC	LRKSLKPLL	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y543	Transcription factor HES-2	DEG_APCC_DBOX_1	13:21	LRKSLKPLL	APC,CDC20,FZR1	0.727	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons