DegronMD

Uniprot ID: Q9NW68

Source protein: BSD domain-containing protein 1

Source gene: BSDC1

Class: DEG_SIAH_1

Location: 269:277

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.997

ASA_SCORE: 98.8556

COIL: 0.9276

CONS_SCORE: 0.2343

DSS_SCORE: 0.6349

HELIX: 0.028

FCONS_SCORE: 0.8524

RIG_SCORE: 0.6554

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T287P	DO48437	BLCA	ICGC	EPPAEVTPS	DEG_SIAH_1	0.0556
p.D266G	DO7798	COAD	ICGC	EPPAEVTPS	DEG_SIAH_1	0.25
p.G263D	DO233207	GACA	ICGC	EPPAEVTPS	DEG_SIAH_1	0.1667
p.P270T	DO229035	LICA	ICGC	EPPAEVTPS	DEG_SIAH_1	0.7031
p.H286Q	DO229037	LICA	ICGC	EPPAEVTPS	DEG_SIAH_1	0.0833
p.V265M	DO23316	LINC	ICGC	EPPAEVTPS	DEG_SIAH_1	0.2222
p.T277M	DO25426	LUAD	ICGC	EPPAEVTPS	DEG_SIAH_1	0.7423
p.T275A	DO38192	STAD	ICGC	EPPAEVTPS	DEG_SIAH_1	0.6028
p.S284L	SIDM01041	Esophageal Carcinoma	GDSC	EPPAEVTPS	DEG_SIAH_1	0.1389
p.S284L	FLO-1	oesophagus	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.1389
p.I263M	SIDM00534	Colorectal Carcinoma	GDSC	EPPAEVTPS	DEG_SIAH_1	0.1667
p.I263M	SIDM00118	Colorectal Carcinoma	GDSC	EPPAEVTPS	DEG_SIAH_1	0.1667
p.I263M	HT-115	large_intestine	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.1667
p.I263M	HCC2998	large_intestine	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.1667
p.Q274R	SIDM00192	Colorectal Carcinoma	GDSC	EPPAEVTPS	DEG_SIAH_1	0.7329
p.E278Q	ACH-000958	Colon/Colorectal Cancer	CCLE	EPPAEVTPS	DEG_SIAH_1	0.3056
p.E278Q	SW48	large_intestine	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.3056
p.S267L	ACH-001500	Esophageal Cancer	CCLE	EPPAEVTPS	DEG_SIAH_1	0.2778
p.S267L	FLO-1	oesophagus	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.2778
p.D269N	NCI-H187	lung	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.6932
p.T283K	8-MG-BA	central_nervous_system	COSMIC	EPPAEVTPS	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NW68	BSD domain-containing protein 1	DEG_SIAH_1	269:277	EPPAEVTPS	SIAH1,SIAH2,SIAH3	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons