DegronMD

Uniprot ID: Q5HY64

Source protein: Putative protein FAM47C

Source gene: FAM47C

Class: DEG_COP1_1

Location: 297:306

E3 ligase: COP1

DEGRON score: 0.8969

ASA_SCORE: 94.15

COIL: 0.9681

CONS_SCORE: 0.532

DSS_SCORE: 0.5835

HELIX: 0.0134

FCONS_SCORE: 1.0254

RIG_SCORE: 0.636

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R290C	TCGA-06-5416	GBM	TCGA	EPPETGVPDL	DEG_COP1_1	0.1389
p.R290C	DO10880	GBM	ICGC	EPPETGVPDL	DEG_COP1_1	0.1389
p.H293Y	TCGA-4E-A92E	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	0.2222
p.H293Y	DO223277	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	0.2222
p.R296L	TCGA-77-7463	LUSC	TCGA	EPPETGVPDL	DEG_COP1_1	0.3056
p.R296L	DO26716	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	0.3056
p.G302E	TCGA-78-7147	LUAD	TCGA	EPPETGVPDL	DEG_COP1_1	0.6087
p.G302E	DO24527	LUAD	ICGC	EPPETGVPDL	DEG_COP1_1	0.6087
p.R296W	TCGA-AG-A01Y	READ	TCGA	EPPETGVPDL	DEG_COP1_1	0.3056
p.R296W	DO222875	MELA	ICGC	EPPETGVPDL	DEG_COP1_1	0.3056
p.R296W	DO37396	READ	ICGC	EPPETGVPDL	DEG_COP1_1	0.3056
p.R314C	TCGA-AJ-A23O	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	0.1111
p.R314C	TCGA-EI-6506	READ	TCGA	EPPETGVPDL	DEG_COP1_1	0.1111
p.R314C	DO36780	READ	ICGC	EPPETGVPDL	DEG_COP1_1	0.1111
p.R314C	DO43290	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	0.1111
p.V315I	TCGA-AX-A2HC	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	0.0833
p.V315I	DO41572	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	0.0833
p.D305N	TCGA-B5-A0JZ	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	0.6932
p.D305N	DO42761	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	0.6932
p.D305A	TCGA-BS-A0UV	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	0.7793
p.D305A	DO42793	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	0.7793
p.E309Q	TCGA-D8-A1X8	BRCA	TCGA	EPPETGVPDL	DEG_COP1_1	0.25
p.E309Q	DO5095	BRCA	ICGC	EPPETGVPDL	DEG_COP1_1	0.25
p.E309K	TCGA-EE-A2GB	SKCM	TCGA	EPPETGVPDL	DEG_COP1_1	0.25
p.E309K	DO222683	MELA	ICGC	EPPETGVPDL	DEG_COP1_1	0.25
p.E309K	DO37417	SKCM	ICGC	EPPETGVPDL	DEG_COP1_1	0.25
p.S313P	TCGA-F7-A624	HNSC	TCGA	EPPETGVPDL	DEG_COP1_1	0.1389
p.S313P	DO44440	HNSC	ICGC	EPPETGVPDL	DEG_COP1_1	0.1389
p.P298S	TCGA-HC-A6HX	PRAD	TCGA	EPPETGVPDL	DEG_COP1_1	0.5641
p.P298S	DO46806	PRAD	ICGC	EPPETGVPDL	DEG_COP1_1	0.5641
p.P299T	TCGA-L3-A524	LUSC	TCGA	EPPETGVPDL	DEG_COP1_1	0.5919
p.P299T	DO45476	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	0.5919
p.P299H	TCGA-L3-A524	LUSC	TCGA	EPPETGVPDL	DEG_COP1_1	0.6583
p.P299H	DO45476	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	0.6583
p.L308P	DO7934	COAD	ICGC	EPPETGVPDL	DEG_COP1_1	0.2778
p.R290L	DO231072	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	0.1389
p.H293P	DO228584	MALY	ICGC	EPPETGVPDL	DEG_COP1_1	0.2222
p.S313L	DO229456	SKCA	ICGC	EPPETGVPDL	DEG_COP1_1	0.1389
p.R296Q	SIDM00231	Kidney Carcinoma	GDSC	EPPETGVPDL	DEG_COP1_1	0.3056
p.R296Q	ACH-002167	Kidney Cancer	CCLE	EPPETGVPDL	DEG_COP1_1	0.3056
p.R296Q	NCC010	kidney	COSMIC	EPPETGVPDL	DEG_COP1_1	0.3056
p.H293Q	SIDM00860	Head and Neck Carcinoma	GDSC	EPPETGVPDL	DEG_COP1_1	0.2222
p.H293Q	ACH-000846	Head and Neck Cancer	CCLE	EPPETGVPDL	DEG_COP1_1	0.2222
p.H293Q	FADU	upper_aerodigestive_tract	COSMIC	EPPETGVPDL	DEG_COP1_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EPPETGVPDL

Degron related mutations and impact score

Drug responses associated with FAM47C mutations

All proteins holding degron of EPPETGVPDL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5HY64	Putative protein FAM47C	DEG_COP1_1	297:306	EPPETGVPDL	COP1	0.8969	More...