DegronMD - Q5HY64(FAM47C)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R290C	TCGA-06-5416	GBM	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.R290C	DO10880	GBM	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.P206T	TCGA-37-4132	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7031
p.P206T	DO26528	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7031
p.H293Y	TCGA-4E-A92E	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.H293Y	DO223277	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.V207E	TCGA-55-A48X	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.6582
p.V207E	DO24048	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.6582
p.P212R	TCGA-69-7974	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.25
p.P212R	DO23850	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.25
p.R296L	TCGA-77-7463	LUSC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.R296L	DO26716	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.G302E	TCGA-78-7147	LUAD	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.6087
p.G302E	DO24527	LUAD	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.6087
p.R194L	TCGA-85-A50Z	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.R194L	DO228998	LICA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.R194L	DO45462	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.R296W	TCGA-AG-A01Y	READ	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.R296W	DO222875	MELA	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.R296W	DO37396	READ	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.R314C	TCGA-AJ-A23O	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1111
p.R314C	TCGA-EI-6506	READ	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1111
p.R314C	DO36780	READ	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1111
p.R314C	DO43290	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1111
p.P206L	TCGA-AP-A056	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	DO218673	GACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	DO43971	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	SIDM00333	Endometrial Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	SIDM01619	Endometrial Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	ACH-000053	Lymphoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	MFE-319	endometrium	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.P206L	KARPAS-299	haematopoietic and lymphoid tissue	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.7582
p.R211H	TCGA-AP-A056	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211H	DO233693	GACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211H	DO34032	PACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211H	DO232663	PBCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211H	DO43971	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.V315I	TCGA-AX-A2HC	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.0833
p.V315I	DO41572	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.0833
p.R194Q	TCGA-AZ-6601	COAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.R194Q	DO8119	COAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.D305N	TCGA-B5-A0JZ	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.6932
p.D305N	DO42761	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.6932
p.R211C	TCGA-BR-A4QL	STAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211C	TCGA-K4-A5RI	BLCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211C	TCGA-P5-A731	LGG	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211C	DO219029	BLCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211C	DO219832	LGG	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211C	DO218860	SKCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.R211C	DO38723	STAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.D305A	TCGA-BS-A0UV	UCEC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.7793
p.D305A	DO42793	UCEC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.7793
p.E213K	TCGA-C5-A2LY	CESC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2222
p.E213K	DO6314	CESC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2222
p.P200Q	TCGA-D3-A5GR	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.P200Q	DO47436	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.2778
p.E309Q	TCGA-D8-A1X8	BRCA	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.E309Q	DO5095	BRCA	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.S196F	TCGA-D9-A6EC	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1667
p.S196F	DO50291	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1667
p.E309K	TCGA-EE-A2GB	SKCM	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.E309K	DO222683	MELA	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.E309K	DO37417	SKCM	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.25
p.S208T	TCGA-EK-A2PM	CESC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.6005
p.S208T	DO49941	CESC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation altering degron motif	0.6005
p.S313P	TCGA-F7-A624	HNSC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.S313P	DO44440	HNSC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.E192K	TCGA-G4-6586	COAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.0556
p.E192K	TCGA-VQ-A91D	STAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.0556
p.E192K	DO9698	COAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.0556
p.E192K	DO51783	STAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.0556
p.P298S	TCGA-HC-A6HX	PRAD	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.5641
p.P298S	DO46806	PRAD	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.5641
p.P299T	TCGA-L3-A524	LUSC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.5919
p.P299T	DO45476	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.5919
p.P299H	TCGA-L3-A524	LUSC	TCGA	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.6583
p.P299H	DO45476	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation altering degron motif	0.6583
p.T217S	TCGA-MB-A5Y9	SARC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.T217S	DO220206	SARC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.C197F	TCGA-QQ-A5VA	SARC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.C197F	DO220246	SARC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.C197S	TCGA-VS-A8EK	CESC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.C197S	DO51623	CESC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1944
p.L308P	DO7934	COAD	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2778
p.R290L	DO231072	LUSC	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.H293P	DO228584	MALY	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.S313L	DO229456	SKCA	ICGC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.1389
p.T217I	SIDM00120	Prostate Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.T217I	ACH-000979	Prostate Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.T217I	DU-145	prostate	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	202:209	Mutation rewiring degron network	0.1111
p.R296Q	SIDM00231	Kidney Carcinoma	GDSC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.R296Q	ACH-002167	Kidney Cancer	CCLE	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.R296Q	NCC010	kidney	COSMIC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.3056
p.H293Q	SIDM00860	Head and Neck Carcinoma	GDSC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.H293Q	ACH-000846	Head and Neck Cancer	CCLE	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222
p.H293Q	FADU	upper aerodigestive tract	COSMIC	EPPETGVPDL	DEG_COP1_1	297:306	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM47C

UniProt ID: Q5HY64

Entrez ID: 442444

Protein name: Putative protein FAM47C

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM47C in