DegronMD

Uniprot ID: Q5HY64

Source protein: Putative protein FAM47C

Source gene: FAM47C

Class: DEG_SCF_FBW7_1

Location: 202:209

E3 ligase: FBXW7

DEGRON score: 0.9165

ASA_SCORE: 92.325

COIL: 0.9618

CONS_SCORE: 0.5435

DSS_SCORE: 0.6844

HELIX: 0.015

FCONS_SCORE: 0.9797

RIG_SCORE: 0.5714

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P206T	TCGA-37-4132	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7031
p.P206T	DO26528	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7031
p.V207E	TCGA-55-A48X	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.6582
p.V207E	DO24048	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.6582
p.P212R	TCGA-69-7974	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P212R	DO23850	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R194L	TCGA-85-A50Z	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R194L	DO228998	LICA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R194L	DO45462	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P206L	TCGA-AP-A056	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	DO218673	GACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	DO43971	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	SIDM00333	Endometrial Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	SIDM01010	T-Cell Non-Hodgkin's Lymphoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	SIDM01619	Endometrial Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	ACH-000053	Lymphoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	ACH-000984	Endometrial/Uterine Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	ACH-000988	Endometrial/Uterine Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	MFE-319	endometrium	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P206L	KARPAS-299	haematopoietic_and_lymphoid_tissue	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.R211H	TCGA-AP-A056	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211H	DO233693	GACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211H	DO34032	PACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211H	DO232663	PBCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211H	DO43971	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R194Q	TCGA-AZ-6601	COAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R194Q	DO8119	COAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R211C	TCGA-BR-A4QL	STAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211C	TCGA-K4-A5RI	BLCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211C	TCGA-P5-A731	LGG	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211C	DO219029	BLCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211C	DO219832	LGG	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211C	DO218860	SKCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R211C	DO38723	STAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.E213K	TCGA-C5-A2LY	CESC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2222
p.E213K	DO6314	CESC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2222
p.P200Q	TCGA-D3-A5GR	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P200Q	DO47436	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.S196F	TCGA-D9-A6EC	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.S196F	DO50291	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.S208T	TCGA-EK-A2PM	CESC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.6005
p.S208T	DO49941	CESC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.6005
p.E192K	TCGA-G4-6586	COAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E192K	TCGA-VQ-A91D	STAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E192K	DO9698	COAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E192K	DO51783	STAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.T217S	TCGA-MB-A5Y9	SARC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.T217S	DO220206	SARC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.C197F	TCGA-QQ-A5VA	SARC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.C197F	DO220246	SARC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.C197S	TCGA-VS-A8EK	CESC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.C197S	DO51623	CESC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1944
p.T217I	SIDM00120	Prostate Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.T217I	ACH-000979	Prostate Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.T217I	DU-145	prostate	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JRC9	Protein FAM47A	DEG_SCF_FBW7_1	215:222	PPKTPVSS	FBXW7	0.6875	More...
Q5JRC9	Protein FAM47A	DEG_SCF_FBW7_1	317:324	PPKTPVSS	FBXW7	0.8088	More...
Q5HY64	Putative protein FAM47C	DEG_SCF_FBW7_1	202:209	PPKTPVSS	FBXW7	0.9165	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPKTPVSS

Degron related mutations and impact score

Drug responses associated with FAM47C mutations

All proteins holding degron of PPKTPVSS