DegronMD

Uniprot ID: Q5JRC9

Source protein: Protein FAM47A

Source gene: FAM47A

Class: DEG_SCF_FBW7_1

Location: 317:324

E3 ligase: FBXW7

DEGRON score: 0.8088

ASA_SCORE: 92.925

COIL: 0.95

CONS_SCORE: 0.3623

DSS_SCORE: 0.7654

HELIX: 0.0216

FCONS_SCORE: 0.8259

RIG_SCORE: 0.5885

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P330T	TCGA-06-5859	GBM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330T	DO12466	GBM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.T332N	TCGA-56-8622	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.T332N	DO45449	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.R326C	TCGA-A6-6781	COAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R326C	TCGA-CN-5369	HNSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R326C	DO8447	COAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R326C	DO16069	HNSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R326C	ACH-001134	Lymphoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P330L	TCGA-AX-A2IN	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330L	DO42328	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330L	SIDM00971	Breast Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330L	ACH-000828	Breast Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330L	ZR-75-30	breast	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.E307K	TCGA-BS-A0UV	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E307K	TCGA-HZ-A49H	PAAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E307K	DO32799	PAAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E307K	DO42793	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.R314C	TCGA-EE-A20H	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.R314C	DO37986	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.G333E	TCGA-EE-A29T	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.G333E	DO37742	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.R314H	TCGA-L5-A4OW	ESCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P317T	TCGA-P3-A6T5	HNSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7031
p.P317T	DO49066	HNSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7031
p.E328K	DO230323	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2222
p.R326H	DO233864	GACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R326P	DO50917	LICA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.PE327PK	DO222363	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0
p.P309T	SIDM00509	Small Cell Lung Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P309T	ACH-000187	Lung Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P309T	COR-L311	lung	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P317H	SIDM00350	Head and Neck Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.7694
p.P317H	ACH-001641	Head and Neck Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.7694
p.P317H	SAT	upper_aerodigestive_tract	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.7694
p.T320S	SIDM00090	Ovarian Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.7116
p.K319N	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.5806
p.K319N	ACH-000309	Lung Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.5806
p.K319N	SK-LU-1	lung	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.5806
p.P330A	SIDM00971	Breast Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330A	ACH-000828	Breast Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P330A	ZR-75-30	breast	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.1667
p.P327R	SIDM00863	Burkitt's Lymphoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.L313F	ACH-000877	Lymphoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPKTPVSS

Degron related mutations and impact score

Drug responses associated with FAM47A mutations

All proteins holding degron of PPKTPVSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JRC9	Protein FAM47A	DEG_SCF_FBW7_1	215:222	PPKTPVSS	FBXW7	0.6875	More...
Q5JRC9	Protein FAM47A	DEG_SCF_FBW7_1	317:324	PPKTPVSS	FBXW7	0.8088	More...
Q5HY64	Putative protein FAM47C	DEG_SCF_FBW7_1	202:209	PPKTPVSS	FBXW7	0.9165	More...