DegronMD

Uniprot ID: Q5JRC9

Source protein: Protein FAM47A

Source gene: FAM47A

Class: DEG_SCF_FBW7_1

Location: 215:222

E3 ligase: FBXW7

DEGRON score: 0.6875

ASA_SCORE: 91.4

COIL: 0.9535

CONS_SCORE: 0.2838

DSS_SCORE: 0.7243

HELIX: 0.0229

FCONS_SCORE: 0.9299

RIG_SCORE: 0.5474

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R224H	TCGA-2H-A9GF	ESCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.R224H	DO234093	THCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.V220L	TCGA-49-AARE	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.5654
p.V220L	DO218922	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.5654
p.P225R	TCGA-50-6593	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P225R	DO24100	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P219L	TCGA-78-7153	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	TCGA-AJ-A3EL	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	TCGA-BR-8363	STAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	TCGA-D9-A4Z3	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	DO230311	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	DO26347	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	DO47555	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	DO47837	STAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	DO41542	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	SIDM00454	Rhabdomyosarcoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	ACH-000689	Sarcoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.P219L	RH-18	soft_tissue	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.7582
p.L211I	TCGA-AP-A1DR	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2222
p.L211I	DO43747	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2222
p.P213Q	TCGA-BF-A3DJ	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P213Q	DO51237	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.T218P	TCGA-CN-A641	HNSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7031
p.T218P	DO44436	HNSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7031
p.T230S	TCGA-DI-A1NN	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.T230S	DO41911	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.1111
p.P213L	TCGA-EO-A22R	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P213L	TCGA-EY-A1GQ	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P213L	DO43090	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P213L	DO42713	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.E205K	TCGA-GN-A266	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E205K	DO37432	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.P215H	TCGA-NC-A5HP	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.7694
p.P215H	DO219199	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.7694
p.R224L	TCGA-P6-A5OG	ACC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.P213T	TCGA-Z6-A9VB	ESCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	0.2778
p.V232L	DO227634	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0556
p.E214G	DO52438	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.3056
p.P216L	DO50970	LICA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.6471
p.P219S	DO222498	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.6752
p.G231E	DO222632	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.0833
p.P225S	DO222837	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P215S	SIDM00619	Thyroid Gland Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.6752
p.P215S	ACH-002397	Thyroid Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	0.6752
p.P215S	KMH-2	thyroid	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.6752
p.P225L	SIDM00971	Breast Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P225L	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.P225L	ZR-75-30	breast	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	0.25
p.L211P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.2222
p.L211P	SIDM01098	Neuroblastoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPKTPVSS

Degron related mutations and impact score

Drug responses associated with FAM47A mutations

All proteins holding degron of PPKTPVSS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JRC9	Protein FAM47A	DEG_SCF_FBW7_1	215:222	PPKTPVSS	FBXW7	0.6875	More...
Q5JRC9	Protein FAM47A	DEG_SCF_FBW7_1	317:324	PPKTPVSS	FBXW7	0.8088	More...
Q5HY64	Putative protein FAM47C	DEG_SCF_FBW7_1	202:209	PPKTPVSS	FBXW7	0.9165	More...