DegronMD - Q5JRC9(FAM47A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P330T	TCGA-06-5859	GBM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330T	DO12466	GBM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.R224H	TCGA-2H-A9GF	ESCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.R224H	DO234093	THCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.V220L	TCGA-49-AARE	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.5654
p.V220L	DO218922	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.5654
p.P225R	TCGA-50-6593	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.25
p.P225R	DO24100	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.25
p.T332N	TCGA-56-8622	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1111
p.T332N	DO45449	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1111
p.P219L	TCGA-78-7153	LUAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	TCGA-AJ-A3EL	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	TCGA-BR-8363	STAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	TCGA-D9-A4Z3	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	DO230311	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	DO26347	LUAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	DO47555	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	DO47837	STAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	DO41542	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	SIDM00454	Rhabdomyosarcoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	ACH-000689	Sarcoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.P219L	RH-18	soft tissue	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7582
p.R326C	TCGA-A6-6781	COAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.R326C	TCGA-CN-5369	HNSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.R326C	DO8447	COAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.R326C	DO16069	HNSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.R326C	ACH-001134	Lymphoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.L211I	TCGA-AP-A1DR	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2222
p.L211I	DO43747	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2222
p.P330L	TCGA-AX-A2IN	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330L	DO42328	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330L	SIDM00971	Breast Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330L	ACH-000828	Breast Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330L	ZR-75-30	breast	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P213Q	TCGA-BF-A3DJ	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.P213Q	DO51237	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.E307K	TCGA-BS-A0UV	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.0556
p.E307K	TCGA-HZ-A49H	PAAD	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.0556
p.E307K	DO32799	PAAD	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.0556
p.E307K	DO42793	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.0556
p.T218P	TCGA-CN-A641	HNSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7031
p.T218P	DO44436	HNSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7031
p.T230S	TCGA-DI-A1NN	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1111
p.T230S	DO41911	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.1111
p.R314C	TCGA-EE-A20H	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.25
p.R314C	DO37986	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.25
p.G333E	TCGA-EE-A29T	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.0833
p.G333E	DO37742	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.0833
p.P213L	TCGA-EO-A22R	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.P213L	TCGA-EY-A1GQ	UCEC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.P213L	DO43090	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.P213L	DO42713	UCEC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.E205K	TCGA-GN-A266	SKCM	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0556
p.E205K	DO37432	SKCM	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0556
p.R314H	TCGA-L5-A4OW	ESCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.25
p.P215H	TCGA-NC-A5HP	LUSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7694
p.P215H	DO219199	LUSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.7694
p.P317T	TCGA-P3-A6T5	HNSC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.7031
p.P317T	DO49066	HNSC	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.7031
p.R224L	TCGA-P6-A5OG	ACC	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.P213T	TCGA-Z6-A9VB	ESCA	TCGA	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2778
p.E328K	DO230323	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2222
p.V232L	DO227634	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0556
p.E214G	DO52438	COCA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.3056
p.R326H	DO233864	GACA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.P216L	DO50970	LICA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.6471
p.R326P	DO50917	LICA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2778
p.PE327PK	DO222363	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0
p.P219S	DO222498	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.6752
p.G231E	DO222632	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.0833
p.P225S	DO222837	MELA	ICGC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.25
p.P309T	SIDM00509	Small Cell Lung Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1111
p.P309T	ACH-000187	Lung Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1111
p.P309T	COR-L311	lung	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1111
p.P317H	SIDM00350	Head and Neck Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.7694
p.P317H	ACH-001641	Head and Neck Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.7694
p.P317H	SAT	upper aerodigestive tract	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.7694
p.T320S	SIDM00090	Ovarian Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.7116
p.P215S	SIDM00619	Thyroid Gland Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.6752
p.P215S	ACH-002397	Thyroid Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.6752
p.P215S	KMH-2	thyroid	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation altering degron motif	0.6752
p.K319N	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.5806
p.K319N	ACH-000309	Lung Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.5806
p.K319N	SK-LU-1	lung	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation altering degron motif	0.5806
p.P330A	SIDM00971	Breast Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330A	ACH-000828	Breast Cancer	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P330A	ZR-75-30	breast	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.1667
p.P225L	SIDM00971	Breast Carcinoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.25
p.P225L	SIDM01686	Chronic Myelogenous Leukemia	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.25
p.P225L	ZR-75-30	breast	COSMIC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.25
p.L211P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2222
p.L211P	SIDM01098	Neuroblastoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	215:222	Mutation rewiring degron network	0.2222
p.P327R	SIDM00863	Burkitt's Lymphoma	GDSC	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.25
p.L313F	ACH-000877	Lymphoma	CCLE	PPKTPVSS	DEG_SCF_FBW7_1	317:324	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM47A

UniProt ID: Q5JRC9

Entrez ID: 158724

Protein name: Protein FAM47A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM47A in