DegronMD

Uniprot ID: A1IGU5

Source protein: Rho guanine nucleotide exchange factor 37

Source gene: ARHGEF37

Class: DEG_COP1_1

Location: 592:601

E3 ligase: COP1

DEGRON score: 0.9975

ASA_SCORE: 85.38

COIL: 0.9473

CONS_SCORE: 0.3715

DSS_SCORE: 0.442

HELIX: 0.0158

FCONS_SCORE: 0.9822

RIG_SCORE: 0.7025

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T603I	TCGA-23-1030	OV	TCGA	EPSPALVPSI	DEG_COP1_1	0.2778
p.T603I	DO31400	OV	ICGC	EPSPALVPSI	DEG_COP1_1	0.2778
p.S600C	TCGA-C5-A1MQ	CESC	TCGA	EPSPALVPSI	DEG_COP1_1	0.8652
p.S600C	DO49001	CESC	ICGC	EPSPALVPSI	DEG_COP1_1	0.8652
p.A609S	TCGA-DU-6392	LGG	TCGA	EPSPALVPSI	DEG_COP1_1	0.1111
p.A609S	DO22237	LGG	ICGC	EPSPALVPSI	DEG_COP1_1	0.1111
p.E592K	TCGA-EE-A29L	SKCM	TCGA	EPSPALVPSI	DEG_COP1_1	0.7022
p.E592K	TCGA-GN-A266	SKCM	TCGA	EPSPALVPSI	DEG_COP1_1	0.7022
p.E592K	DO220886	MELA	ICGC	EPSPALVPSI	DEG_COP1_1	0.7022
p.E592K	DO222599	MELA	ICGC	EPSPALVPSI	DEG_COP1_1	0.7022
p.E592K	DO37835	SKCM	ICGC	EPSPALVPSI	DEG_COP1_1	0.7022
p.E592K	DO37432	SKCM	ICGC	EPSPALVPSI	DEG_COP1_1	0.7022
p.M604T	TCGA-EO-A22T	UCEC	TCGA	EPSPALVPSI	DEG_COP1_1	0.25
p.M604T	DO42320	UCEC	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.M604I	TCGA-WE-AAA3	SKCM	TCGA	EPSPALVPSI	DEG_COP1_1	0.25
p.M604I	DO51295	SKCM	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.P586T	DO228483	BRCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO230334	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO222804	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO229010	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO229013	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO229016	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO51029	LAML	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO51021	LAML	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.P586T	DO51004	LAML	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.M604V	DO222866	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.M604V	DO229010	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.M604V	DO229013	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.M604V	DO229016	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.M604V	DO229003	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.M604V	DO229005	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.25
p.V607F	DO229022	LICA	ICGC	EPSPALVPSI	DEG_COP1_1	0.1667
p.A596S	DO229037	LICA	ICGC	EPSPALVPSI	DEG_COP1_1	0.6477
p.S594I	DO50707	ORCA	ICGC	EPSPALVPSI	DEG_COP1_1	0.7341
p.P602L	SIDM00007	Other Solid Cancers	GDSC	EPSPALVPSI	DEG_COP1_1	0.3056
p.P602L	ACH-001550	Skin Cancer	CCLE	EPSPALVPSI	DEG_COP1_1	0.3056
p.P602L	MCC13	skin	COSMIC	EPSPALVPSI	DEG_COP1_1	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EPSPALVPSI

Degron related mutations and impact score

Drug responses associated with ARHGEF37 mutations

All proteins holding degron of EPSPALVPSI

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1IGU5	Rho guanine nucleotide exchange factor 37	DEG_COP1_1	592:601	EPSPALVPSI	COP1	0.9975	More...