DegronMD - A1IGU5(ARHGEF37)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T603I	TCGA-23-1030	OV	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.2778
p.T603I	TCGA-23-1030	OV	TCGA	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0833
p.T603I	DO31400	OV	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.2778
p.T603I	DO31400	OV	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0833
p.R232Q	TCGA-A5-A1OF	UCEC	TCGA	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7329
p.R232Q	DO42568	UCEC	ICGC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7329
p.R234W	TCGA-B5-A3FC	UCEC	TCGA	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7523
p.R234W	DO41871	UCEC	ICGC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.7523
p.S600C	TCGA-C5-A1MQ	CESC	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.8652
p.S600C	DO49001	CESC	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.8652
p.L235M	TCGA-DU-6392	LGG	TCGA	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.711
p.L235M	DO22237	LGG	ICGC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.711
p.A609S	TCGA-DU-6392	LGG	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1111
p.A609S	DO22237	LGG	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1111
p.R234Q	TCGA-EA-A410	CESC	TCGA	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6218
p.R234Q	DO49929	CESC	ICGC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.6218
p.L243I	TCGA-EE-A29E	SKCM	TCGA	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2222
p.L243I	DO37831	SKCM	ICGC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2222
p.E592K	TCGA-EE-A29L	SKCM	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7022
p.E592K	TCGA-EE-A29L	SKCM	TCGA	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.591
p.E592K	TCGA-GN-A266	SKCM	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7022
p.E592K	TCGA-GN-A266	SKCM	TCGA	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.591
p.E592K	DO220886	MELA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7022
p.E592K	DO220886	MELA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.591
p.E592K	DO222599	MELA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7022
p.E592K	DO222599	MELA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.591
p.E592K	DO37835	SKCM	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7022
p.E592K	DO37835	SKCM	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.591
p.E592K	DO37432	SKCM	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7022
p.E592K	DO37432	SKCM	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.591
p.M604T	TCGA-EO-A22T	UCEC	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604T	TCGA-EO-A22T	UCEC	TCGA	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604T	DO42320	UCEC	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604T	DO42320	UCEC	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604I	TCGA-WE-AAA3	SKCM	TCGA	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604I	TCGA-WE-AAA3	SKCM	TCGA	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604I	DO51295	SKCM	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604I	DO51295	SKCM	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.P586T	DO228483	BRCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO228483	BRCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO230334	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO230334	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO222804	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO222804	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO229010	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO229010	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO229013	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO229013	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO229016	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO229016	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO51029	LAML	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO51029	LAML	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO51021	LAML	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO51021	LAML	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.P586T	DO51004	LAML	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.P586T	DO51004	LAML	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.25
p.M604V	DO222866	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604V	DO222866	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604V	DO229010	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604V	DO229010	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604V	DO229013	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604V	DO229013	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604V	DO229016	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604V	DO229016	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604V	DO229003	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604V	DO229003	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.M604V	DO229005	COCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.25
p.M604V	DO229005	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.A580V	DO233882	GACA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0833
p.V607F	DO229022	LICA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.1667
p.A596S	DO229037	LICA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.6477
p.S594I	DO50707	ORCA	ICGC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation altering degron motif	0.7341
p.S594I	DO50707	ORCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation altering degron motif	0.7341
p.Q579P	DO71843	THCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.Q579H	SIDM00120	Prostate Carcinoma	GDSC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.Q579H	ACH-000979	Prostate Cancer	CCLE	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.Q579H	DU-145	prostate	COSMIC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.0556
p.P602L	SIDM00007	Other Solid Cancers	GDSC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.3056
p.P602L	SIDM00007	Other Solid Cancers	GDSC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.1111
p.P602L	ACH-001550	Skin Cancer	CCLE	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.3056
p.P602L	ACH-001550	Skin Cancer	CCLE	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.1111
p.P602L	MCC13	skin	COSMIC	EPSPALVPSI	DEG_COP1_1	592:601	Mutation rewiring degron network	0.3056
p.P602L	MCC13	skin	COSMIC	LTPEPS	DEG_SCF_FBW7_1	589:594	Mutation rewiring degron network	0.1111
p.L229P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2778
p.L229P	ACH-000937	Leukemia	CCLE	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2778
p.L229P	PF-382	haematopoietic and lymphoid tissue	COSMIC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.2778
p.R249W	SIDM01619	Endometrial Carcinoma	GDSC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.R249W	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation rewiring degron network	0.0556
p.N239K	ACH-001626	Head and Neck Cancer	CCLE	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.5806
p.N239K	OSC-20	upper aerodigestive tract	COSMIC	LRERLARIN	DEG_APCC_DBOX_1	231:239	Mutation altering degron motif	0.5806

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF37

UniProt ID: A1IGU5

Entrez ID: 389337

Protein name: Rho guanine nucleotide exchange factor 37

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ARHGEF37 in