DegronMD

Uniprot ID: A1IGU5

Source protein: Rho guanine nucleotide exchange factor 37

Source gene: ARHGEF37

Class: DEG_APCC_DBOX_1

Location: 231:239

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5822

ASA_SCORE: 95.9

COIL: 0.3517

CONS_SCORE: 0.3642

DSS_SCORE: 0.3379

HELIX: 0.622

FCONS_SCORE: 0.8692

RIG_SCORE: 0.8299

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R232Q	TCGA-A5-A1OF	UCEC	TCGA	LRERLARIN	DEG_APCC_DBOX_1	0.7329
p.R232Q	DO42568	UCEC	ICGC	LRERLARIN	DEG_APCC_DBOX_1	0.7329
p.R234W	TCGA-B5-A3FC	UCEC	TCGA	LRERLARIN	DEG_APCC_DBOX_1	0.7523
p.R234W	DO41871	UCEC	ICGC	LRERLARIN	DEG_APCC_DBOX_1	0.7523
p.L235M	TCGA-DU-6392	LGG	TCGA	LRERLARIN	DEG_APCC_DBOX_1	0.711
p.L235M	DO22237	LGG	ICGC	LRERLARIN	DEG_APCC_DBOX_1	0.711
p.R234Q	TCGA-EA-A410	CESC	TCGA	LRERLARIN	DEG_APCC_DBOX_1	0.6218
p.R234Q	DO49929	CESC	ICGC	LRERLARIN	DEG_APCC_DBOX_1	0.6218
p.L243I	TCGA-EE-A29E	SKCM	TCGA	LRERLARIN	DEG_APCC_DBOX_1	0.2222
p.L243I	DO37831	SKCM	ICGC	LRERLARIN	DEG_APCC_DBOX_1	0.2222
p.L229P	SIDM00451	T-Lymphoblastic Leukemia	GDSC	LRERLARIN	DEG_APCC_DBOX_1	0.2778
p.L229P	ACH-000937	Leukemia	CCLE	LRERLARIN	DEG_APCC_DBOX_1	0.2778
p.L229P	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LRERLARIN	DEG_APCC_DBOX_1	0.2778
p.R249W	SIDM01619	Endometrial Carcinoma	GDSC	LRERLARIN	DEG_APCC_DBOX_1	0.0556
p.R249W	ACH-000984	Endometrial/Uterine Cancer	CCLE	LRERLARIN	DEG_APCC_DBOX_1	0.0556
p.N239K	ACH-001626	Head and Neck Cancer	CCLE	LRERLARIN	DEG_APCC_DBOX_1	0.5806
p.N239K	OSC-20	upper_aerodigestive_tract	COSMIC	LRERLARIN	DEG_APCC_DBOX_1	0.5806

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1IGU5	Rho guanine nucleotide exchange factor 37	DEG_APCC_DBOX_1	231:239	LRERLARIN	APC,CDC20,FZR1	0.5822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons