DegronMD

Uniprot ID: A1IGU5

Source protein: Rho guanine nucleotide exchange factor 37

Source gene: ARHGEF37

Class: DEG_SCF_FBW7_1

Location: 589:594

E3 ligase: FBXW7

DEGRON score: 0.9931

ASA_SCORE: 87.1667

COIL: 0.966

CONS_SCORE: 0.33

DSS_SCORE: 0.4999

HELIX: 0.0132

FCONS_SCORE: 0.9078

RIG_SCORE: 0.6925

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T603I	TCGA-23-1030	OV	TCGA	LTPEPS	DEG_SCF_FBW7_1	0.0833
p.T603I	DO31400	OV	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0833
p.E592K	TCGA-EE-A29L	SKCM	TCGA	LTPEPS	DEG_SCF_FBW7_1	0.591
p.E592K	TCGA-GN-A266	SKCM	TCGA	LTPEPS	DEG_SCF_FBW7_1	0.591
p.E592K	DO220886	MELA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.591
p.E592K	DO222599	MELA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.591
p.E592K	DO37835	SKCM	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.591
p.E592K	DO37432	SKCM	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.591
p.M604T	TCGA-EO-A22T	UCEC	TCGA	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604T	DO42320	UCEC	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604I	TCGA-WE-AAA3	SKCM	TCGA	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604I	DO51295	SKCM	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.P586T	DO228483	BRCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO230334	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO222804	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO229010	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO229013	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO229016	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO51029	LAML	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO51021	LAML	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.P586T	DO51004	LAML	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.25
p.M604V	DO222866	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604V	DO229010	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604V	DO229013	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604V	DO229016	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604V	DO229003	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.M604V	DO229005	COCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.A580V	DO233882	GACA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0833
p.S594I	DO50707	ORCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.7341
p.Q579P	DO71843	THCA	ICGC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.Q579H	SIDM00120	Prostate Carcinoma	GDSC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.Q579H	ACH-000979	Prostate Cancer	CCLE	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.Q579H	DU-145	prostate	COSMIC	LTPEPS	DEG_SCF_FBW7_1	0.0556
p.P602L	SIDM00007	Other Solid Cancers	GDSC	LTPEPS	DEG_SCF_FBW7_1	0.1111
p.P602L	ACH-001550	Skin Cancer	CCLE	LTPEPS	DEG_SCF_FBW7_1	0.1111
p.P602L	MCC13	skin	COSMIC	LTPEPS	DEG_SCF_FBW7_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPEPS

Degron related mutations and impact score

Drug responses associated with ARHGEF37 mutations

All proteins holding degron of LTPEPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1IGU5	Rho guanine nucleotide exchange factor 37	DEG_SCF_FBW7_1	589:594	LTPEPS	FBXW7	0.9931	More...