DegronMD

Uniprot ID: Q53GG5

Source protein: PDZ and LIM domain protein 3

Source gene: PDLIM3

Class: DEG_SIAH_1

Location: 222:230

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9892

ASA_SCORE: 76.7778

COIL: 0.9041

CONS_SCORE: 0.3683

DSS_SCORE: 0.6354

HELIX: 0.056

FCONS_SCORE: 0.8008

RIG_SCORE: 0.6323

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D239N	TCGA-AA-A02E	COAD	TCGA	EPTASVPPE	DEG_SIAH_1	0.0833
p.S226L	TCGA-AZ-4315	COAD	TCGA	EPTASVPPE	DEG_SIAH_1	0.6556
p.S226L	TCGA-VR-A8EO	ESCA	TCGA	EPTASVPPE	DEG_SIAH_1	0.6556
p.S226L	DO8842	COAD	ICGC	EPTASVPPE	DEG_SIAH_1	0.6556
p.S226L	DO218068	GACA	ICGC	EPTASVPPE	DEG_SIAH_1	0.6556
p.S226L	DO233779	GACA	ICGC	EPTASVPPE	DEG_SIAH_1	0.6556
p.H238D	TCGA-CV-A45Z	HNSC	TCGA	EPTASVPPE	DEG_SIAH_1	0.1111
p.H238D	DO52064	HNSC	ICGC	EPTASVPPE	DEG_SIAH_1	0.1111
p.E230K	DO229389	BTCA	ICGC	EPTASVPPE	DEG_SIAH_1	0.591
p.E230K	SIDM00193	Colorectal Carcinoma	GDSC	EPTASVPPE	DEG_SIAH_1	0.591
p.E230K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	EPTASVPPE	DEG_SIAH_1	0.591
p.E230K	SNU-81	large_intestine	COSMIC	EPTASVPPE	DEG_SIAH_1	0.591
p.E230K	KYSE-150	oesophagus	COSMIC	EPTASVPPE	DEG_SIAH_1	0.591
p.A213T	DO233882	GACA	ICGC	EPTASVPPE	DEG_SIAH_1	0.0833
p.G235D	DO46657	PAAD	ICGC	EPTASVPPE	DEG_SIAH_1	0.1944
p.T231M	DO33091	PACA	ICGC	EPTASVPPE	DEG_SIAH_1	0.3056
p.A240G	DO218888	SKCA	ICGC	EPTASVPPE	DEG_SIAH_1	0.0556
p.L237F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	EPTASVPPE	DEG_SIAH_1	0.1389
p.L237F	REH	haematopoietic_and_lymphoid_tissue	COSMIC	EPTASVPPE	DEG_SIAH_1	0.1389
p.N240S	SIDM00799	Glioblastoma	GDSC	EPTASVPPE	DEG_SIAH_1	0.0556
p.N240S	A172	central_nervous_system	COSMIC	EPTASVPPE	DEG_SIAH_1	0.0556
p.P228L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	EPTASVPPE	DEG_SIAH_1	0.6471
p.P228L	NCI-H1563	lung	COSMIC	EPTASVPPE	DEG_SIAH_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GG5	PDZ and LIM domain protein 3	DEG_SIAH_1	222:230	EPTASVPPE	SIAH1,SIAH2,SIAH3	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons