DegronMD - Q53GG5(PDLIM3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G215A	TCGA-09-2049	OV	TCGA	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6429
p.G215A	DO29488	OV	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6429
p.G215W	TCGA-66-2734	LUSC	TCGA	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6714
p.G215W	DO26430	LUSC	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6714
p.N201S	TCGA-78-7155	LUAD	TCGA	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.N201S	DO23590	LUAD	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.D239N	TCGA-AA-A02E	COAD	TCGA	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.0833
p.S226L	TCGA-AZ-4315	COAD	TCGA	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6556
p.S226L	TCGA-VR-A8EO	ESCA	TCGA	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6556
p.S226L	DO8842	COAD	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6556
p.S226L	DO218068	GACA	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6556
p.S226L	DO233779	GACA	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6556
p.H238D	TCGA-CV-A45Z	HNSC	TCGA	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.1111
p.H238D	DO52064	HNSC	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.1111
p.P193H	TCGA-DF-A2KN	UCEC	TCGA	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.3056
p.P193H	DO223282	UCEC	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.3056
p.P218S	TCGA-DK-A1A3	BLCA	TCGA	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6752
p.P218S	DO558	BLCA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6752
p.P218S	DO52663	MALY	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.6752
p.M220L	DO1096	BRCA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.5999
p.R219H	DO219633	BRCA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.8244
p.R219H	DO233731	GACA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.8244
p.E230K	DO229389	BTCA	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.591
p.E230K	SIDM00193	Colorectal Carcinoma	GDSC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.591
p.E230K	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.591
p.E230K	SNU-81	large intestine	COSMIC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.591
p.E230K	KYSE-150	oesophagus	COSMIC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.591
p.Y186C	DO230312	COCA	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1111
p.R187Q	DO230330	COCA	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1389
p.A213T	DO233882	GACA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation rewiring degron network	0.3056
p.A213T	DO233882	GACA	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.0833
p.Q201H	DO219691	KIRP	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.R219S	DO231652	LINC	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.7427
p.S202L	DO228349	MALY	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.S202L	ACH-000944	Lymphoma	CCLE	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.S202L	NAMALWA	haematopoietic and lymphoid tissue	COSMIC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.25
p.G235D	DO46657	PAAD	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.1944
p.T231M	DO33091	PACA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation rewiring degron network	0.0556
p.T231M	DO33091	PACA	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.3056
p.A240G	DO218888	SKCA	ICGC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.0556
p.S189L	DO38099	SKCM	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1944
p.R193Q	DO42568	UCEC	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.3056
p.R200H	DO41223	UCEC	ICGC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.3056
p.L237F	SIDM00447	B-Lymphoblastic Leukemia	GDSC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.1389
p.L237F	REH	haematopoietic and lymphoid tissue	COSMIC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.1389
p.N240S	SIDM00799	Glioblastoma	GDSC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.0556
p.N240S	A172	central nervous system	COSMIC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation rewiring degron network	0.0556
p.P228L	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6471
p.P228L	NCI-H1563	lung	COSMIC	EPTASVPPE	DEG_SIAH_1	222:230	Mutation altering degron motif	0.6471
p.S198T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation altering degron motif	0.6005
p.S198T	ACH-000945	Lung Cancer	CCLE	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation altering degron motif	0.6005
p.S198T	NCI-H650	lung	COSMIC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation altering degron motif	0.6005
p.N192S	ACH-000558	Brain Cancer	CCLE	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.N192S	A172	central nervous system	COSMIC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.2778
p.P220T	ACH-000706	Lung Cancer	CCLE	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.7031
p.P220T	EKVX	lung	COSMIC	LGETPLMS	DEG_SCF_FBW7_1	214:221	Mutation altering degron motif	0.7031
p.L189F	ACH-000960	Leukemia	CCLE	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1944
p.L189F	REH	haematopoietic and lymphoid tissue	COSMIC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.1944
p.P185S	VM-CUB-1	urinary tract	COSMIC	MQLYSD	LIG_APCC_ABBA_1	194:199	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDLIM3

UniProt ID: Q53GG5

Entrez ID: 27295

Protein name: PDZ and LIM domain protein 3 (Actinin-associated LIM protein) (Alpha-actinin-2-associated LIM protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDLIM3 in