DegronMD

Uniprot ID: Q53GG5

Source protein: PDZ and LIM domain protein 3

Source gene: PDLIM3

Class: DEG_SCF_FBW7_1

Location: 214:221

E3 ligase: FBXW7

DEGRON score: 0.9389

ASA_SCORE: 74.575

COIL: 0.846

CONS_SCORE: 0.4266

DSS_SCORE: 0.6081

HELIX: 0.0699

FCONS_SCORE: 0.9322

RIG_SCORE: 0.672

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R219H	DO219633	BRCA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.8244
p.R219H	DO233731	GACA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.8244
p.R219S	DO231652	LINC	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.7427
p.P220T	ACH-000706	Lung Cancer	CCLE	LGETPLMS	DEG_SCF_FBW7_1	0.7031
p.P220T	EKVX	lung	COSMIC	LGETPLMS	DEG_SCF_FBW7_1	0.7031
p.P218S	TCGA-DK-A1A3	BLCA	TCGA	LGETPLMS	DEG_SCF_FBW7_1	0.6752
p.P218S	DO558	BLCA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.6752
p.P218S	DO52663	MALY	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.6752
p.G215W	TCGA-66-2734	LUSC	TCGA	LGETPLMS	DEG_SCF_FBW7_1	0.6714
p.G215W	DO26430	LUSC	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.6714
p.G215A	TCGA-09-2049	OV	TCGA	LGETPLMS	DEG_SCF_FBW7_1	0.6429
p.G215A	DO29488	OV	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.6429
p.M220L	DO1096	BRCA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.5999
p.A213T	DO233882	GACA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.3056
p.T231M	DO33091	PACA	ICGC	LGETPLMS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 15 of 15 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GG5	PDZ and LIM domain protein 3	DEG_SCF_FBW7_1	214:221	LGETPLMS	FBXW7	0.9389	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons