DegronMD

Uniprot ID: Q53GG5

Source protein: PDZ and LIM domain protein 3

Source gene: PDLIM3

Class: LIG_APCC_ABBA_1

Location: 194:199

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9546

ASA_SCORE: 73.4667

COIL: 0.7458

CONS_SCORE: 0.6633

DSS_SCORE: 0.3577

HELIX: 0.1842

FCONS_SCORE: 1.2045

RIG_SCORE: 0.8

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N201S	TCGA-78-7155	LUAD	TCGA	MQLYSD	LIG_APCC_ABBA_1	0.2778
p.N201S	DO23590	LUAD	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.2778
p.P193H	TCGA-DF-A2KN	UCEC	TCGA	MQLYSD	LIG_APCC_ABBA_1	0.3056
p.P193H	DO223282	UCEC	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.3056
p.Y186C	DO230312	COCA	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.1111
p.R187Q	DO230330	COCA	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.1389
p.Q201H	DO219691	KIRP	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.2778
p.S202L	DO228349	MALY	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.25
p.S202L	ACH-000944	Lymphoma	CCLE	MQLYSD	LIG_APCC_ABBA_1	0.25
p.S202L	NAMALWA	haematopoietic_and_lymphoid_tissue	COSMIC	MQLYSD	LIG_APCC_ABBA_1	0.25
p.S189L	DO38099	SKCM	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.1944
p.R193Q	DO42568	UCEC	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.3056
p.R200H	DO41223	UCEC	ICGC	MQLYSD	LIG_APCC_ABBA_1	0.3056
p.S198T	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	MQLYSD	LIG_APCC_ABBA_1	0.6005
p.S198T	ACH-000945	Lung Cancer	CCLE	MQLYSD	LIG_APCC_ABBA_1	0.6005
p.S198T	NCI-H650	lung	COSMIC	MQLYSD	LIG_APCC_ABBA_1	0.6005
p.N192S	ACH-000558	Brain Cancer	CCLE	MQLYSD	LIG_APCC_ABBA_1	0.2778
p.N192S	A172	central_nervous_system	COSMIC	MQLYSD	LIG_APCC_ABBA_1	0.2778
p.L189F	ACH-000960	Leukemia	CCLE	MQLYSD	LIG_APCC_ABBA_1	0.1944
p.L189F	REH	haematopoietic_and_lymphoid_tissue	COSMIC	MQLYSD	LIG_APCC_ABBA_1	0.1944
p.P185S	VM-CUB-1	urinary_tract	COSMIC	MQLYSD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53GG5	PDZ and LIM domain protein 3	LIG_APCC_ABBA_1	194:199	MQLYSD	APC,CDC20,FZR1	0.9546	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons