DegronMD

Uniprot ID: Q8ND61

Source protein: Uncharacterized protein C3orf20

Source gene: C3orf20

Class: DEG_COP1_1

Location: 82:91

E3 ligase: COP1

DEGRON score: 0.5062

ASA_SCORE: 92.21

COIL: 0.8296

CONS_SCORE: 0.2653

DSS_SCORE: 0.2797

HELIX: 0.0634

FCONS_SCORE: 0.7507

RIG_SCORE: 0.8068

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P76S	TCGA-AB-2833	LAML	TCGA	EPTFVQVPTL	DEG_COP1_1	0.1667
p.P76S	DO21679	LAML	ICGC	EPTFVQVPTL	DEG_COP1_1	0.1667
p.E82K	TCGA-EE-A29E	SKCM	TCGA	EPTFVQVPTL	DEG_COP1_1	0.7022
p.E82K	TCGA-FW-A3R5	SKCM	TCGA	EPTFVQVPTL	DEG_COP1_1	0.7022
p.E82K	DO37831	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	0.7022
p.E82K	DO37406	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	0.7022
p.P100A	TCGA-F4-6856	COAD	TCGA	EPTFVQVPTL	DEG_COP1_1	0.0833
p.P100A	DO9114	COAD	ICGC	EPTFVQVPTL	DEG_COP1_1	0.0833
p.P100A	SIDM00602	Gastric Carcinoma	GDSC	EPTFVQVPTL	DEG_COP1_1	0.0833
p.P100A	ACH-000919	Gastric Cancer	CCLE	EPTFVQVPTL	DEG_COP1_1	0.0833
p.V88A	TCGA-VQ-A8P2	STAD	TCGA	EPTFVQVPTL	DEG_COP1_1	0.6936
p.G96R	DO51886	BLCA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.1944
p.A90T	DO8842	COAD	ICGC	EPTFVQVPTL	DEG_COP1_1	0.7139
p.A90T	DO38312	STAD	ICGC	EPTFVQVPTL	DEG_COP1_1	0.7139
p.L84F	DO228976	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.6981
p.S72I	DO229027	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.0556
p.S80I	DO229031	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.2778
p.A75S	DO229038	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.1389
p.A101P	DO229052	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.0556
p.S77R	DO23448	LINC	ICGC	EPTFVQVPTL	DEG_COP1_1	0.1944
p.N98K	DO49873	LUAD	ICGC	EPTFVQVPTL	DEG_COP1_1	0.1389
p.A94T	DO34616	PACA	ICGC	EPTFVQVPTL	DEG_COP1_1	0.25
p.G75E	DO37559	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	0.1389
p.Y101D	DO37831	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	0.0556
p.A94V	DO48618	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	0.25
p.P83T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	EPTFVQVPTL	DEG_COP1_1	0.5919
p.P83T	ACH-000920	Leukemia	CCLE	EPTFVQVPTL	DEG_COP1_1	0.5919
p.G74E	SIDM01746	Osteosarcoma	GDSC	EPTFVQVPTL	DEG_COP1_1	0.1111
p.G74E	ACH-000154	Non-Cancerous	CCLE	EPTFVQVPTL	DEG_COP1_1	0.1111
p.M81I	ACH-001566	Skin Cancer	CCLE	EPTFVQVPTL	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND61	Uncharacterized protein C3orf20	DEG_COP1_1	82:91	EPTFVQVPTL	COP1	0.5062	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: EPTFVQVPTL

Degron related mutations and impact score

Drug responses associated with C3orf20 mutations

All proteins holding degron of EPTFVQVPTL