DegronMD - Q8ND61(C3orf20)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C279F	TCGA-69-7979	LUAD	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1389
p.P260L	TCGA-A6-6138	COAD	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1667
p.P260L	SIDM01608	Endometrial Carcinoma	GDSC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1667
p.P260L	ACH-000990	Endometrial/Uterine Cancer	CCLE	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1667
p.S258I	TCGA-A8-A06X	BRCA	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1111
p.P76S	TCGA-AB-2833	LAML	TCGA	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1667
p.P76S	DO21679	LAML	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1667
p.D256N	TCGA-AX-A06F	UCEC	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.0556
p.N271S	TCGA-AX-A06F	UCEC	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.5958
p.E274Q	TCGA-E7-A6MD	BLCA	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.2778
p.E82K	TCGA-EE-A29E	SKCM	TCGA	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.7022
p.E82K	TCGA-FW-A3R5	SKCM	TCGA	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.7022
p.E82K	DO37831	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.7022
p.E82K	DO37406	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.7022
p.P269L	TCGA-EE-A2MN	SKCM	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.7582
p.P269S	TCGA-EE-A3AB	SKCM	TCGA	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.6752
p.P100A	TCGA-F4-6856	COAD	TCGA	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0833
p.P100A	DO9114	COAD	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0833
p.P100A	SIDM00602	Gastric Carcinoma	GDSC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0833
p.P100A	ACH-000919	Gastric Cancer	CCLE	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0833
p.V88A	TCGA-VQ-A8P2	STAD	TCGA	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.6936
p.F257L	DO51945	BLCA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.0833
p.F257L	DO223597	BLCA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.0833
p.G96R	DO51886	BLCA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1944
p.A90T	DO8842	COAD	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.7139
p.A90T	DO38312	STAD	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.7139
p.Q275H	DO8722	COAD	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.25
p.Q275H	DO229041	LICA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.25
p.S268P	DO233732	GACA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.6752
p.L84F	DO228976	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.6981
p.S72I	DO229027	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0556
p.S80I	DO229031	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.2778
p.C280F	DO229035	LICA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1111
p.A75S	DO229038	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1389
p.A101P	DO229052	LICA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0556
p.S77R	DO23448	LINC	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1944
p.N98K	DO49873	LUAD	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1389
p.S268Y	DO24110	LUAD	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.712
p.P267S	DO222875	MELA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.6752
p.G269E	DO222837	MELA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.7199
p.C280R	DO233295	NACA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1111
p.A94T	DO34616	PACA	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.25
p.G75E	DO37559	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1389
p.Y101D	DO37831	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.0556
p.R281I	DO37413	SKCM	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.0833
p.A94V	DO48618	SKCM	ICGC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.25
p.P267H	DO40190	THCA	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.7694
p.G260D	DO42033	UCEC	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation rewiring degron network	0.1667
p.V271I	DO42280	UCEC	ICGC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.7076
p.P83T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.5919
p.P83T	ACH-000920	Leukemia	CCLE	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation altering degron motif	0.5919
p.N271K	SIDM00877	Breast Carcinoma	GDSC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.5806
p.N271K	ACH-000196	Breast Cancer	CCLE	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.5806
p.S272C	SIDM00877	Breast Carcinoma	GDSC	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.7541
p.S272C	ACH-000196	Breast Cancer	CCLE	VGTPANS	DEG_SCF_FBW7_1	266:272	Mutation altering degron motif	0.7541
p.G74E	SIDM01746	Osteosarcoma	GDSC	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1111
p.G74E	ACH-000154	Non-Cancerous	CCLE	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.1111
p.M81I	ACH-001566	Skin Cancer	CCLE	EPTFVQVPTL	DEG_COP1_1	82:91	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C3orf20

UniProt ID: Q8ND61

Entrez ID: 84077

Protein name: Uncharacterized protein C3orf20

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C3orf20 in