DegronMD

Uniprot ID: Q8ND61

Source protein: Uncharacterized protein C3orf20

Source gene: C3orf20

Class: DEG_SCF_FBW7_1

Location: 266:272

E3 ligase: FBXW7

DEGRON score: 0.9696

ASA_SCORE: 68.0429

COIL: 0.7999

CONS_SCORE: 0.3224

DSS_SCORE: 0.5632

HELIX: 0.1444

FCONS_SCORE: 0.9083

RIG_SCORE: 0.6219

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C279F	TCGA-69-7979	LUAD	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.1389
p.P260L	TCGA-A6-6138	COAD	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.1667
p.P260L	SIDM01608	Endometrial Carcinoma	GDSC	VGTPANS	DEG_SCF_FBW7_1	0.1667
p.P260L	ACH-000990	Endometrial/Uterine Cancer	CCLE	VGTPANS	DEG_SCF_FBW7_1	0.1667
p.S258I	TCGA-A8-A06X	BRCA	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.1111
p.D256N	TCGA-AX-A06F	UCEC	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.0556
p.N271S	TCGA-AX-A06F	UCEC	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.5958
p.E274Q	TCGA-E7-A6MD	BLCA	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.2778
p.P269L	TCGA-EE-A2MN	SKCM	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.7582
p.P269S	TCGA-EE-A3AB	SKCM	TCGA	VGTPANS	DEG_SCF_FBW7_1	0.6752
p.F257L	DO51945	BLCA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.0833
p.F257L	DO223597	BLCA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.0833
p.Q275H	DO8722	COAD	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.25
p.Q275H	DO229041	LICA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.25
p.S268P	DO233732	GACA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.6752
p.C280F	DO229035	LICA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.1111
p.S268Y	DO24110	LUAD	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.712
p.P267S	DO222875	MELA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.6752
p.G269E	DO222837	MELA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.7199
p.C280R	DO233295	NACA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.1111
p.R281I	DO37413	SKCM	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.0833
p.P267H	DO40190	THCA	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.7694
p.G260D	DO42033	UCEC	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.1667
p.V271I	DO42280	UCEC	ICGC	VGTPANS	DEG_SCF_FBW7_1	0.7076
p.N271K	SIDM00877	Breast Carcinoma	GDSC	VGTPANS	DEG_SCF_FBW7_1	0.5806
p.N271K	ACH-000196	Breast Cancer	CCLE	VGTPANS	DEG_SCF_FBW7_1	0.5806
p.S272C	SIDM00877	Breast Carcinoma	GDSC	VGTPANS	DEG_SCF_FBW7_1	0.7541
p.S272C	ACH-000196	Breast Cancer	CCLE	VGTPANS	DEG_SCF_FBW7_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8ND61	Uncharacterized protein C3orf20	DEG_SCF_FBW7_1	266:272	VGTPANS	FBXW7	0.9696	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGTPANS

Degron related mutations and impact score

Drug responses associated with C3orf20 mutations

All proteins holding degron of VGTPANS