DegronMD

Uniprot ID: A6NE01

Source protein: Protein FAM186A

Source gene: FAM186A

Class: DEG_APCC_DBOX_1

Location: 2034:2042

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9776

ASA_SCORE: 105.0556

COIL: 0.7447

CONS_SCORE: 0.3841

DSS_SCORE: 0.4163

HELIX: 0.2256

FCONS_SCORE: 0.9973

RIG_SCORE: 0.8394

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2035M	TCGA-B5-A3FA	UCEC	TCGA	ERALLTLMK	DEG_APCC_DBOX_1	0.8632
p.R2035M	DO52402	UCEC	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	0.8632
p.L2050V	DO228941	LICA	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	0.1111
p.T2029N	DO229009	LICA	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	0.1944
p.A2036T	DO220906	MELA	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	0.6028

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NE01	Protein FAM186A	DEG_APCC_DBOX_1	2034:2042	ERALLTLMK	APC,CDC20,FZR1	0.9776	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons