DegronMD - A6NE01(FAM186A)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1124I	TCGA-AP-A059	UCEC	TCGA	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.0833
p.T1124I	DO41361	UCEC	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.0833
p.E1037D	TCGA-AP-A0LM	UCEC	TCGA	ISITPPPS	DEG_SCF_FBW7_1	1046:1053	Mutation rewiring degron network	0.0833
p.E1037D	TCGA-FI-A2D0	UCEC	TCGA	ISITPPPS	DEG_SCF_FBW7_1	1046:1053	Mutation rewiring degron network	0.0833
p.E1037D	DO43306	UCEC	ICGC	ISITPPPS	DEG_SCF_FBW7_1	1046:1053	Mutation rewiring degron network	0.0833
p.E1037D	DO43891	UCEC	ICGC	ISITPPPS	DEG_SCF_FBW7_1	1046:1053	Mutation rewiring degron network	0.0833
p.R2035M	TCGA-B5-A3FA	UCEC	TCGA	ERALLTLMK	DEG_APCC_DBOX_1	2034:2042	Mutation altering degron motif	0.8632
p.R2035M	DO52402	UCEC	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	2034:2042	Mutation altering degron motif	0.8632
p.A1130V	TCGA-DF-A2KN	UCEC	TCGA	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.25
p.A1130V	DO223282	UCEC	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.25
p.N943S	TCGA-EO-A3AY	UCEC	TCGA	EKENG	DEG_APCC_KENBOX_2	940:944	Mutation altering degron motif	0.7069
p.N943S	DO43202	UCEC	ICGC	EKENG	DEG_APCC_KENBOX_2	940:944	Mutation altering degron motif	0.7069
p.K931T	TCGA-EO-A3B0	UCEC	TCGA	EKENG	DEG_APCC_KENBOX_2	940:944	Mutation substituting flanking lysine	0.1944
p.K931T	DO219773	UCEC	ICGC	EKENG	DEG_APCC_KENBOX_2	940:944	Mutation substituting flanking lysine	0.1944
p.D1041N	DO522	BLCA	ICGC	ISITPPPS	DEG_SCF_FBW7_1	1046:1053	Mutation rewiring degron network	0.1944
p.P1149H	DO233259	GACA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.0833
p.T1140A	DO228919	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7139
p.T1140A	DO228938	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7139
p.T1140A	DO228937	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7139
p.T1140A	DO228974	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7139
p.T1140A	DO229051	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7139
p.T1140A	ACH-000985	Colon/Colorectal Cancer	CCLE	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation altering degron motif	0.7139
p.L2050V	DO228941	LICA	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	2034:2042	Mutation rewiring degron network	0.1111
p.T2029N	DO229009	LICA	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	2034:2042	Mutation rewiring degron network	0.1944
p.F1123L	DO228355	MALY	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.0556
p.A2036T	DO220906	MELA	ICGC	ERALLTLMK	DEG_APCC_DBOX_1	2034:2042	Mutation altering degron motif	0.6028
p.K933E	DO46933	RECA	ICGC	EKENG	DEG_APCC_KENBOX_2	940:944	Mutation substituting flanking lysine	0.25
p.V1142A	DO218884	SKCA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	1133:1140	Mutation rewiring degron network	0.2778
p.E1037A	ACH-000884	Skin Cancer	CCLE	ISITPPPS	DEG_SCF_FBW7_1	1046:1053	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM186A

UniProt ID: A6NE01

Entrez ID: 121006

Protein name: Protein FAM186A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM186A in