DegronMD

Uniprot ID: A6NE01

Source protein: Protein FAM186A

Source gene: FAM186A

Class: DEG_SCF_FBW7_1

Location: 1133:1140

E3 ligase: FBXW7

DEGRON score: 0.9601

ASA_SCORE: 88.2

COIL: 0.9441

CONS_SCORE: 0.4362

DSS_SCORE: 0.3743

HELIX: 0.0164

FCONS_SCORE: 0.9777

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1124I	TCGA-AP-A059	UCEC	TCGA	IPLTPQQT	DEG_SCF_FBW7_1	0.0833
p.T1124I	DO41361	UCEC	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.0833
p.A1130V	TCGA-DF-A2KN	UCEC	TCGA	IPLTPQQT	DEG_SCF_FBW7_1	0.25
p.A1130V	DO223282	UCEC	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.25
p.P1149H	DO233259	GACA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.0833
p.T1140A	DO228919	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.7139
p.T1140A	DO228938	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.7139
p.T1140A	DO228937	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.7139
p.T1140A	DO228974	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.7139
p.T1140A	DO229051	LICA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.7139
p.T1140A	ACH-000985	Colon/Colorectal Cancer	CCLE	IPLTPQQT	DEG_SCF_FBW7_1	0.7139
p.F1123L	DO228355	MALY	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.0556
p.V1142A	DO218884	SKCA	ICGC	IPLTPQQT	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NE01	Protein FAM186A	DEG_SCF_FBW7_1	1133:1140	IPLTPQQT	FBXW7	0.9601	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons