DegronMD

Uniprot ID: A6NE01

Source protein: Protein FAM186A

Source gene: FAM186A

Class: DEG_SCF_FBW7_1

Location: 1046:1053

E3 ligase: FBXW7

DEGRON score: 0.9992

ASA_SCORE: 77.275

COIL: 0.9534

CONS_SCORE: 0.503

DSS_SCORE: 0.5726

HELIX: 0.0119

FCONS_SCORE: 1.1673

RIG_SCORE: 0.6803

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1037D	TCGA-AP-A0LM	UCEC	TCGA	ISITPPPS	DEG_SCF_FBW7_1	0.0833
p.E1037D	TCGA-FI-A2D0	UCEC	TCGA	ISITPPPS	DEG_SCF_FBW7_1	0.0833
p.E1037D	DO43306	UCEC	ICGC	ISITPPPS	DEG_SCF_FBW7_1	0.0833
p.E1037D	DO43891	UCEC	ICGC	ISITPPPS	DEG_SCF_FBW7_1	0.0833
p.D1041N	DO522	BLCA	ICGC	ISITPPPS	DEG_SCF_FBW7_1	0.1944
p.E1037A	ACH-000884	Skin Cancer	CCLE	ISITPPPS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6NE01	Protein FAM186A	DEG_SCF_FBW7_1	1046:1053	ISITPPPS	FBXW7	0.9992	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons