DegronMD

Uniprot ID: A6NE01

Source protein: Protein FAM186A

Source gene: FAM186A

Class: DEG_APCC_KENBOX_2

Location: 940:944

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5071

ASA_SCORE: 107.58

COIL: 0.8244

CONS_SCORE: 0.4646

DSS_SCORE: 0.6422

HELIX: 0.1176

FCONS_SCORE: 1.0262

RIG_SCORE: 0.7135

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N943S	TCGA-EO-A3AY	UCEC	TCGA	EKENG	DEG_APCC_KENBOX_2	0.7069
p.N943S	DO43202	UCEC	ICGC	EKENG	DEG_APCC_KENBOX_2	0.7069
p.K931T	TCGA-EO-A3B0	UCEC	TCGA	EKENG	DEG_APCC_KENBOX_2	0.1944
p.K931T	DO219773	UCEC	ICGC	EKENG	DEG_APCC_KENBOX_2	0.1944
p.K933E	DO46933	RECA	ICGC	EKENG	DEG_APCC_KENBOX_2	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons