DegronMD

Uniprot ID: Q9BXL8

Source protein: Cell division cycle-associated protein 4

Source gene: CDCA4

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9956

ASA_SCORE: 79.4778

COIL: 0.6372

CONS_SCORE: 0.6591

DSS_SCORE: 0.3739

HELIX: 0.3134

FCONS_SCORE: 1.0796

RIG_SCORE: 0.8036

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R80C	TCGA-B5-A0JR	UCEC	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R80C	TCGA-BR-8368	STAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R80C	DO47981	STAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R80C	DO41791	UCEC	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R103C	TCGA-BR-4361	STAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	0.1389
p.R103C	DO38887	STAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1389
p.R103C	SIDM00217	Colorectal Carcinoma	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1389
p.R103C	ACH-000999	Colon/Colorectal Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	0.1389
p.R103C	SNU-1040	large_intestine	COSMIC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1389
p.R94C	TCGA-CG-4460	STAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	0.719
p.R94C	DO38427	STAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.719
p.R94C	DO233980	THCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.719
p.R89Q	TCGA-D5-6930	COAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	0.7329
p.R89Q	TCGA-F7-A50G	HNSC	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	0.7329
p.R89Q	DO10550	COAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.7329
p.R89Q	DO49067	HNSC	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.7329
p.R89W	DO227985	COCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.8634
p.R94H	DO227987	COCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.7133
p.R94H	DO228732	GACA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.7133
p.R80H	DO229010	COCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R80H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R80H	ACH-000964	Leukemia	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.L92R	DO233284	GACA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.8428
p.A105V	DO35242	PACA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	0.0833
p.A105V	ACH-001030	Bone Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	0.0833
p.A105T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	0.0833
p.A105T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	0.0833
p.A105T	ACH-000995	Leukemia	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	0.0833
p.A105T	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ERAPLDRLV	DEG_APCC_DBOX_1	0.0833
p.R94L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	0.7316
p.R94L	ACH-000875	Lung Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	0.7316
p.R94L	NCI-H2347	lung	COSMIC	ERAPLDRLV	DEG_APCC_DBOX_1	0.7316
p.R80L	SIDM01511	Gastric Carcinoma	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	0.1111
p.R103H	ACH-001845	Bile Duct Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERAPLDRLV

Degron related mutations and impact score

Drug responses associated with CDCA4 mutations

All proteins holding degron of ERAPLDRLV

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXL8	Cell division cycle-associated protein 4	DEG_APCC_DBOX_1	88:96	ERAPLDRLV	APC,CDC20,FZR1	0.9956	More...