DegronMD - Q9BXL8(CDCA4)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E230K	TCGA-AO-A126	BRCA	TCGA	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.0833
p.E230K	DO3638	BRCA	ICGC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.0833
p.R80C	TCGA-B5-A0JR	UCEC	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R80C	TCGA-BR-8368	STAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R80C	DO47981	STAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R80C	DO41791	UCEC	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R103C	TCGA-BR-4361	STAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.R103C	DO38887	STAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.R103C	SIDM00217	Colorectal Carcinoma	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.R103C	ACH-000999	Colon/Colorectal Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.R103C	SNU-1040	large intestine	COSMIC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.R94C	TCGA-CG-4460	STAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.719
p.R94C	DO38427	STAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.719
p.R94C	DO233980	THCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.719
p.R89Q	TCGA-D5-6930	COAD	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.R89Q	TCGA-F7-A50G	HNSC	TCGA	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.R89Q	DO10550	COAD	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.R89Q	DO49067	HNSC	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7329
p.P220S	TCGA-DA-A1IA	SKCM	TCGA	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation altering degron motif	0.5641
p.P220S	DO38022	SKCM	ICGC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation altering degron motif	0.5641
p.R89W	DO227985	COCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8634
p.R94H	DO227987	COCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7133
p.R94H	DO228732	GACA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7133
p.R80H	DO229010	COCA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R80H	SIDM00153	T-Lymphoblastic Leukemia	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R80H	ACH-000964	Leukemia	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.L92R	DO233284	GACA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8428
p.G205C	DO233885	GACA	ICGC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.0556
p.G209V	DO52391	LUSC	ICGC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1667
p.A105V	DO35242	PACA	ICGC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.A105V	ACH-001030	Bone Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.G212S	SIDM00422	Hodgkin's Lymphoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.25
p.G212S	ACH-001203	Lymphoma	CCLE	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.25
p.G212S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.25
p.A105T	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.A105T	SIDM01263	T-Lymphoblastic Leukemia	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.A105T	ACH-000995	Leukemia	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.A105T	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.G229R	SIDM00285	Neuroblastoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1111
p.G229R	SIDM00865	Small Cell Lung Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.1111
p.S223T	SIDM00875	Breast Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.S223T	SIDM00479	Esophageal Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.S223T	SIDM00760	Small Cell Lung Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.S223T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	215:221	Mutation rewiring degron network	0.2778
p.R94L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7316
p.R94L	ACH-000875	Lung Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7316
p.R94L	NCI-H2347	lung	COSMIC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7316
p.R80L	SIDM01511	Gastric Carcinoma	GDSC	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1111
p.R103H	ACH-001845	Bile Duct Cancer	CCLE	ERAPLDRLV	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDCA4

UniProt ID: Q9BXL8

Entrez ID: 55038

Protein name: Cell division cycle-associated protein 4 (Hematopoietic progenitor protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDCA4 in