DegronMD

Uniprot ID: Q9BXL8

Source protein: Cell division cycle-associated protein 4

Source gene: CDCA4

Class: DEG_SCF_FBW7_1

Location: 215:221

E3 ligase: FBXW7

DEGRON score: 0.986

ASA_SCORE: 70.8

COIL: 0.9427

CONS_SCORE: 0.4268

DSS_SCORE: 0.5239

HELIX: 0.0277

FCONS_SCORE: 0.6055

RIG_SCORE: 0.6047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E230K	TCGA-AO-A126	BRCA	TCGA	PATPGPS	DEG_SCF_FBW7_1	0.0833
p.E230K	DO3638	BRCA	ICGC	PATPGPS	DEG_SCF_FBW7_1	0.0833
p.P220S	TCGA-DA-A1IA	SKCM	TCGA	PATPGPS	DEG_SCF_FBW7_1	0.5641
p.P220S	DO38022	SKCM	ICGC	PATPGPS	DEG_SCF_FBW7_1	0.5641
p.G205C	DO233885	GACA	ICGC	PATPGPS	DEG_SCF_FBW7_1	0.0556
p.G209V	DO52391	LUSC	ICGC	PATPGPS	DEG_SCF_FBW7_1	0.1667
p.G212S	SIDM00422	Hodgkin's Lymphoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.25
p.G212S	ACH-001203	Lymphoma	CCLE	PATPGPS	DEG_SCF_FBW7_1	0.25
p.G212S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	PATPGPS	DEG_SCF_FBW7_1	0.25
p.G229R	SIDM00285	Neuroblastoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.1111
p.G229R	SIDM00865	Small Cell Lung Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.1111
p.S223T	SIDM00875	Breast Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.2778
p.S223T	SIDM00479	Esophageal Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.2778
p.S223T	SIDM00760	Small Cell Lung Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.2778
p.S223T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PATPGPS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BXL8	Cell division cycle-associated protein 4	DEG_SCF_FBW7_1	215:221	PATPGPS	FBXW7	0.986	More...
Q9ULI3	Protein HEG homolog 1	DEG_SCF_FBW7_1	75:81	PATPGPS	FBXW7	0.9608	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons