DegronMD

Uniprot ID: Q07157

Source protein: Tight junction protein ZO-1

Source gene: TJP1

Class: DEG_APCC_DBOX_1

Location: 264:272

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8528

ASA_SCORE: 81.9778

COIL: 0.6817

CONS_SCORE: 0.2967

DSS_SCORE: 0.3786

HELIX: 0.2474

FCONS_SCORE: 0.7978

RIG_SCORE: 0.7868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R265W	TCGA-AA-3864	COAD	TCGA	ERATLLNVP	DEG_APCC_DBOX_1	0.8634
p.R265W	DO8490	COAD	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	0.8634
p.R265W	DO227549	COCA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	0.8634
p.G254C	TCGA-AX-A063	UCEC	TCGA	ERATLLNVP	DEG_APCC_DBOX_1	0.0556
p.G254C	DO42201	UCEC	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	0.0556
p.P272L	DO225337	BRCA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	0.6471
p.N282D	DO233871	GACA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	0.0556
p.L269S	DO229479	SKCA	ICGC	ERATLLNVP	DEG_APCC_DBOX_1	0.6556
p.R269W	ACH-001184	Sarcoma	CCLE	ERATLLNVP	DEG_APCC_DBOX_1	0.8634
p.D277H	ACH-002113	Bone Cancer	CCLE	ERATLLNVP	DEG_APCC_DBOX_1	0.6389
p.D277H	EW-13	bone	COSMIC	ERATLLNVP	DEG_APCC_DBOX_1	0.6389
p.D261H	EW-13	bone	COSMIC	ERATLLNVP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07157	Tight junction protein ZO-1	DEG_APCC_DBOX_1	264:272	ERATLLNVP	APC,CDC20,FZR1	0.8528	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons