DegronMD

Uniprot ID: P14616

Source protein: Insulin receptor-related protein

Source gene: INSRR

Class: DEG_APCC_DBOX_1

Location: 770:778

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9042

ASA_SCORE: 58.8111

COIL: 0.4164

CONS_SCORE: 0.4001

DSS_SCORE: 0.2766

HELIX: 0.0231

FCONS_SCORE: 0.874

RIG_SCORE: 0.7807

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L774M	SIDM01435	Hepatocellular Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	0.711
p.L774M	ACH-000686	Liver Cancer	CCLE	ERAVLSGLR	DEG_APCC_DBOX_1	0.711
p.S775N	DO232761	PBCA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.7069
p.T781K	DO228971	LICA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.6944
p.A772E	DO229006	LICA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.659
p.G776S	TCGA-BG-A3EW	UCEC	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	0.5882
p.G776S	DO227536	COCA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.5882
p.G776S	DO48172	UCEC	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.5882
p.A772V	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	0.5825
p.R769L	TCGA-49-4514	LUAD	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	0.3056
p.R769L	DO23818	LUAD	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.3056
p.H779Q	SIDM00285	Neuroblastoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	0.3056
p.H779Q	CHP-134	autonomic_ganglia	COSMIC	ERAVLSGLR	DEG_APCC_DBOX_1	0.3056
p.E764K	TCGA-DD-A73C	LIHC	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	0.1667
p.E764K	DO48593	LIHC	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.1667
p.R784Q	SIDM02021	Esophageal Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	0.1667
p.D786N	TCGA-CK-4951	COAD	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	0.1111
p.D786N	DO10582	COAD	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	0.1111
p.H788N	SIDM01409	Bladder Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14616	Insulin receptor-related protein	DEG_APCC_DBOX_1	770:778	ERAVLSGLR	APC,CDC20,FZR1	0.9042	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons