DegronMD - P14616(INSRR)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R769L	TCGA-49-4514	LUAD	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.R769L	DO23818	LUAD	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.R447H	TCGA-AX-A06F	UCEC	TCGA	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation altering degron motif	0.8244
p.R447H	DO41752	UCEC	ICGC	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation altering degron motif	0.8244
p.G776S	TCGA-BG-A3EW	UCEC	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.5882
p.G776S	DO227536	COCA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.5882
p.G776S	DO48172	UCEC	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.5882
p.D786N	TCGA-CK-4951	COAD	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1111
p.D786N	DO10582	COAD	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1111
p.E764K	TCGA-DD-A73C	LIHC	TCGA	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1667
p.E764K	DO48593	LIHC	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1667
p.Y441H	TCGA-DU-6392	LGG	TCGA	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation rewiring degron network	0.1944
p.Y441H	DO22237	LGG	ICGC	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation rewiring degron network	0.1944
p.E451K	TCGA-EO-A22U	UCEC	TCGA	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation altering degron motif	0.591
p.E451K	DO43755	UCEC	ICGC	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation altering degron motif	0.591
p.T781K	DO228971	LICA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation blocking phosphorylation signal	0.6944
p.A772E	DO229006	LICA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.659
p.S775N	DO232761	PBCA	ICGC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.7069
p.R784Q	SIDM02021	Esophageal Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.1667
p.H779Q	SIDM00285	Neuroblastoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.H779Q	CHP-134	autonomic ganglia	COSMIC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.3056
p.T460A	SIDM00140	Melanoma	GDSC	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation rewiring degron network	0.1667
p.T460A	ACH-000968	Skin Cancer	CCLE	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation rewiring degron network	0.1667
p.T460A	COLO-792	skin	COSMIC	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation rewiring degron network	0.1667
p.H788N	SIDM01409	Bladder Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation rewiring degron network	0.0556
p.K439N	SIDM01726	Ewing's Sarcoma	GDSC	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation substituting flanking lysine	0.25
p.K439N	ACH-000119	Non-Cancerous	CCLE	PRLCLEHIY	DEG_APCC_DBOX_1	446:454	Mutation substituting flanking lysine	0.25
p.L774M	SIDM01435	Hepatocellular Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.711
p.L774M	ACH-000686	Liver Cancer	CCLE	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.711
p.A772V	SIDM01762	Esophageal Squamous Cell Carcinoma	GDSC	ERAVLSGLR	DEG_APCC_DBOX_1	770:778	Mutation altering degron motif	0.5825

Kaplan plot for INSRR in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

INSRR

UniProt ID: P14616

Entrez ID: 3645

Protein name: Insulin receptor-related protein (IRR) (EC 2.7.10.1) (IR-related receptor) [Cleaved into: Insulin receptor-related protein alpha chain; Insulin receptor-related protein beta chain]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for INSRR in