DegronMD

Uniprot ID: P14616

Source protein: Insulin receptor-related protein

Source gene: INSRR

Class: DEG_APCC_DBOX_1

Location: 446:454

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8449

ASA_SCORE: 54.8778

COIL: 0.3726

CONS_SCORE: 0.5718

DSS_SCORE: 0.0587

HELIX: 0.6152

FCONS_SCORE: 1.2524

RIG_SCORE: 0.9214

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R447H	TCGA-AX-A06F	UCEC	TCGA	PRLCLEHIY	DEG_APCC_DBOX_1	0.8244
p.R447H	DO41752	UCEC	ICGC	PRLCLEHIY	DEG_APCC_DBOX_1	0.8244
p.Y441H	TCGA-DU-6392	LGG	TCGA	PRLCLEHIY	DEG_APCC_DBOX_1	0.1944
p.Y441H	DO22237	LGG	ICGC	PRLCLEHIY	DEG_APCC_DBOX_1	0.1944
p.E451K	TCGA-EO-A22U	UCEC	TCGA	PRLCLEHIY	DEG_APCC_DBOX_1	0.591
p.E451K	DO43755	UCEC	ICGC	PRLCLEHIY	DEG_APCC_DBOX_1	0.591
p.T460A	SIDM00140	Melanoma	GDSC	PRLCLEHIY	DEG_APCC_DBOX_1	0.1667
p.T460A	ACH-000968	Skin Cancer	CCLE	PRLCLEHIY	DEG_APCC_DBOX_1	0.1667
p.T460A	COLO-792	skin	COSMIC	PRLCLEHIY	DEG_APCC_DBOX_1	0.1667
p.K439N	SIDM01726	Ewing's Sarcoma	GDSC	PRLCLEHIY	DEG_APCC_DBOX_1	0.25
p.K439N	ACH-000119	Non-Cancerous	CCLE	PRLCLEHIY	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14616	Insulin receptor-related protein	DEG_APCC_DBOX_1	446:454	PRLCLEHIY	APC,CDC20,FZR1	0.8449	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons