DegronMD

Uniprot ID: Q9H4Q3

Source protein: PR domain zinc finger protein 13

Source gene: PRDM13

Class: DEG_APCC_DBOX_1

Location: 432:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9721

ASA_SCORE: 76.2111

COIL: 0.6667

CONS_SCORE: 0.4121

DSS_SCORE: 0.3621

HELIX: 0.0146

FCONS_SCORE: 1.0382

RIG_SCORE: 0.7306

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E432K	TCGA-CV-7568	HNSC	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	0.591
p.E432K	DO14160	HNSC	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	0.591
p.G449C	TCGA-D3-A3C7	SKCM	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	0.0833
p.G449C	DO47569	SKCM	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	0.0833
p.Q422K	TCGA-DK-A6AW	BLCA	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	0.0556
p.Q422K	DO48566	BLCA	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	0.0556
p.P438T	TCGA-G9-6499	PRAD	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	0.5919
p.P438T	DO36298	PRAD	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	0.5919
p.P438S	TCGA-HZ-7926	PAAD	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	0.5641
p.P438S	DO32759	PAAD	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	0.5641
p.P448T	DO229027	LICA	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	0.1111
p.A435T	SIDM02068	Esophageal Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6028
p.Y447C	SIDM01198	Burkitt's Lymphoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.1389
p.Y447C	ACH-000567	Lymphoma	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	0.1389
p.Y447C	ST486	haematopoietic_and_lymphoid_tissue	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.1389
p.P437L	SIDM00304	Ovarian Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM00492	Glioblastoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM01172	Acute Myeloid Leukemia	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM00487	Colorectal Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM00580	Acute Myeloid Leukemia	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM01257	Hepatocellular Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM00273	Glioblastoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM01622	Breast Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM00062	Hepatocellular Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	SIDM01391	Neuroblastoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	NOMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	JHOS-3	ovary	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	THP-1	haematopoietic_and_lymphoid_tissue	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	AM-38	central_nervous_system	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	HUH-6-clone5	liver	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	CCK-81	large_intestine	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437L	GI-1	central_nervous_system	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6471
p.P437Q	SIDM01114	Non-Cancerous	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.5924
p.P437Q	PWR-1E	prostate	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.5924
p.L429F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.25
p.L429F	ACH-000951	Lung Cancer	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	0.25
p.L429F	NCI-H2342	lung	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.25
p.R433P	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.7512
p.R433P	ACH-000012	Lung Cancer	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	0.7512
p.R433P	HCC-827	lung	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.7512
p.G428A	SIDM00641	Burkitt's Lymphoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	0.2222
p.D440H	ACH-001496	Esophageal Cancer	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	0.6577
p.D440H	ESO26	oesophagus	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	0.6577

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ERCALPPLD

Degron related mutations and impact score

Drug responses associated with PRDM13 mutations

All proteins holding degron of ERCALPPLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H4Q3	PR domain zinc finger protein 13	DEG_APCC_DBOX_1	432:440	ERCALPPLD	APC,CDC20,FZR1	0.9721	More...