DegronMD - Q9H4Q3(PRDM13)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L607M	TCGA-06-5416	GBM	TCGA	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.5999
p.L607M	DO10880	GBM	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.5999
p.F610L	TCGA-60-2698	LUSC	TCGA	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.6981
p.F610L	DO228460	BRCA	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.6981
p.F610L	DO26469	LUSC	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.6981
p.K599T	TCGA-AJ-A5DW	UCEC	TCGA	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation substituting flanking lysine	0.2222
p.K599T	DO50075	UCEC	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation substituting flanking lysine	0.2222
p.D612G	TCGA-CG-5721	STAD	TCGA	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.7198
p.D612G	DO38192	STAD	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.7198
p.E432K	TCGA-CV-7568	HNSC	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.591
p.E432K	DO14160	HNSC	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.591
p.G449C	TCGA-D3-A3C7	SKCM	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0833
p.G449C	DO47569	SKCM	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0833
p.Q422K	TCGA-DK-A6AW	BLCA	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0556
p.Q422K	DO48566	BLCA	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0556
p.P438T	TCGA-G9-6499	PRAD	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.5919
p.P438T	DO36298	PRAD	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.5919
p.P438S	TCGA-HZ-7926	PAAD	TCGA	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.5641
p.P438S	DO32759	PAAD	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.5641
p.D612N	DO234378	ESAD	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.6932
p.L616P	DO234457	ESAD	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation rewiring degron network	0.2222
p.R621W	DO233867	GACA	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation rewiring degron network	0.0833
p.D612Y	DO228976	LICA	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation altering degron motif	0.7325
p.P448T	DO229027	LICA	ICGC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.1111
p.C606F	DO229034	LICA	ICGC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation rewiring degron network	0.3056
p.A435T	SIDM02068	Esophageal Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6028
p.Y447C	SIDM01198	Burkitt's Lymphoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.1389
p.Y447C	ACH-000567	Lymphoma	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.1389
p.Y447C	ST486	haematopoietic and lymphoid tissue	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.1389
p.P437L	SIDM00304	Ovarian Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM00492	Glioblastoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM01172	Acute Myeloid Leukemia	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM00487	Colorectal Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM00580	Acute Myeloid Leukemia	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM01257	Hepatocellular Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM00273	Glioblastoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM01622	Breast Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM00062	Hepatocellular Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	SIDM01391	Neuroblastoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	JHOS-3	ovary	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	THP-1	haematopoietic and lymphoid tissue	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	AM-38	central nervous system	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	HUH-6-clone5	liver	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	CCK-81	large intestine	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P437L	GI-1	central nervous system	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6471
p.P600L	SIDM01148	Plasma Cell Myeloma	GDSC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation rewiring degron network	0.1389
p.P600L	ACH-000050	Myeloma	CCLE	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation rewiring degron network	0.1389
p.P600L	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	LRPFGD	LIG_APCC_ABBA_1	607:612	Mutation rewiring degron network	0.1389
p.P437Q	SIDM01114	Non-Cancerous	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.5924
p.P437Q	PWR-1E	prostate	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.5924
p.L429F	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.25
p.L429F	ACH-000951	Lung Cancer	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.25
p.L429F	NCI-H2342	lung	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.25
p.R433P	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7512
p.R433P	ACH-000012	Lung Cancer	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7512
p.R433P	HCC-827	lung	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.7512
p.G428A	SIDM00641	Burkitt's Lymphoma	GDSC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.2222
p.D440H	ACH-001496	Esophageal Cancer	CCLE	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6577
p.D440H	ESO26	oesophagus	COSMIC	ERCALPPLD	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6577

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PRDM13

UniProt ID: Q9H4Q3

Entrez ID: 59336

Protein name: PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PRDM13 in